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Histone chaperones: an escort network regulating histone traffic
Nature Structural & Molecular Biology, 2007In eukaryotes, DNA is organized into chromatin in a dynamic manner that enables it to be accessed for processes such as transcription and repair. Histones, the chief protein component of chromatin, must be assembled, replaced or exchanged to preserve or change this organization according to cellular needs.
Leanne, De Koning +3 more
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Structure and function of histone chaperone FACT
Molecular Biology, 2015FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the preservation and recovery of the nucleosome structure during and after transcription, replication and repair of DNA ...
M T, Bondarenko +6 more
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Histone Chaperones, Epigenetics, and Cancer
2013Histone chaperones such as CAF1, ASF1, HIRA, DEK, DAXX, and several others play central roles in the transport, modification, replication, and replacement of nucleosomes. These diverse roles affect many processes including epigenetic memory, genome stability, transcription, Polycomb function, and others.
Mina Rafiei, Rod Bremner
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Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants
BioEssays, 2016Histone variants are specialized histones which replace their canonical counterparts in specific nucleosomes. Together with histone post‐translational modifications and DNA methylation, they contribute to the epigenome. Histone variants are incorporated at specific locations by the concerted action of histone chaperones and ATP‐dependent chromatin ...
Célia, Jeronimo, François, Robert
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Histone Chaperones in Chromatin Dynamics
2007Histone chaperones are the histone interacting factors that stimulate histone transfer reaction without being a part of the final product. They are involved in the histone storage, histone translocation to the nucleus, and histone exchange and histone deposition onto the DNA for replication dependent chromatin assembly.
Jayasha, Shandilya +3 more
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Analysis of Histone and Histone Chaperone Nuclear Import
2017The nuclear import of proteins is a fundamental process required for the proper formation and function of chromatin. Analysis of the nuclear import pathways of the histones, the major protein component of chromatin, and the histone chaperones that mediate their assembly into nucleosomes is important for understanding how chromatin assembly is regulated
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Purification of Histone Variant-Interacting Chaperone Complexes
2018Identification of the interaction partners of a protein is one of useful straightforward methods to gain insight into the molecular functions of the protein in cells. The pre-deposited forms of histones are associated with the specific histone chaperones to assemble into chromatin.
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