Results 231 to 240 of about 17,972 (261)
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network [PDF]
Molecular Cell, 2021 From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear.
Colin M Hammond +2 more
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Histone chaperone networks shaping chromatin function
Nature Reviews Molecular Cell Biology, 2017 The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomic localization. In this way, the chaperoning of soluble histones
Colin M Hammond +2 more
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Histone Chaperones: Assisting Histone Traffic and Nucleosome Dynamics
Annual Review of Biochemistry, 2014The functional organization of eukaryotic DNA into chromatin uses histones as components of its building block, the nucleosome. Histone chaperones, which are proteins that escort histones throughout their cellular life, are key actors in all facets of histone metabolism; they regulate the supply and dynamics of histones at chromatin for its assembly ...
Zachary A Gurard-Levin +2 more
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Histone chaperones, a supporting role in the limelight
Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 2004In eukaryotic cells, highly basic histone proteins are associated with the DNA to form the nucleosome, the fundamental unit of chromatin. Histones are closely escorted by histone chaperones from their point of synthesis up to their delivery site. We will present an overview of the histone chaperones identified to date with their various roles, in an ...
Alejandra Loyola, Genevieve Almouzni
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Histone chaperones and nucleosome assembly
Current Opinion in Structural Biology, 2003Recent structures of the nucleosome core particle reveal details of histone-histone and histone-DNA interactions. These structures have now set the stage for understanding chromatin assembly and dynamics during replication and transcription. Histone chaperones and chromatin remodeling complexes are important in both of these processes.
Christopher W, Akey, Karolin, Luger
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Histone chaperones link histone nuclear import and chromatin assembly [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2012 Histone chaperones are proteins that shield histones from nonspecific interactions until they are assembled into chromatin. After their synthesis in the cytoplasm, histones are bound by different histone chaperones, subjected to a series of posttranslational modifications and imported into the nucleus.
Lucy F Pemberton
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Histone chaperones: an escort network regulating histone traffic
Nature Structural & Molecular Biology, 2007In eukaryotes, DNA is organized into chromatin in a dynamic manner that enables it to be accessed for processes such as transcription and repair. Histones, the chief protein component of chromatin, must be assembled, replaced or exchanged to preserve or change this organization according to cellular needs.
Leanne, De Koning +3 more
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Structure and function of histone chaperone FACT
Molecular Biology, 2015FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the preservation and recovery of the nucleosome structure during and after transcription, replication and repair of DNA ...
M T, Bondarenko +6 more
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H3–H4 Histone Chaperone Pathways
Annual Review of Genetics, 2018Nucleosomes compact and organize genetic material on a structural level. However, they also alter local chromatin accessibility through changes in their position, through the incorporation of histone variants, and through a vast array of histone posttranslational modifications.
Prerna, Grover +2 more
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