Results 201 to 210 of about 66,376 (233)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Novel Eukaryotic Double Histone Fold Motifs Sharing High Sequence Identity with Histones H3 and H4 in Single-Domain Proteins and in Proteins Featuring Remarkable Histone Fold Multiplets. [PDF]

ACS Omega
Ranaudo A, Miyake T, Shehi H, Cosentino U, Orlando M, Nardini M, Greco C.   +6 more
europepmc   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Cryo-EM structures of CENP-A nucleosomes isolated from human cells. [PDF]

Commun Biol
Tanida E, Hatazawa S, Oishi T, Kobayashi Y, Ogasawara M, Jaskiewicz MA, Harada A, Fujii T, Ohkawa Y, Takizawa Y, Kurumizaka H.   +10 more
europepmc   +1 more source

The epigenetic landscape of plant defense: Unlocking nature's toolkit for new plant protection

New Plant Protection, EarlyView.
This review examines how epigenetic mechanisms regulate plant immune gene activation, repression, and priming, then links these natural regulatory layers to emerging epigenetic editing, discussing their potential for precise, heritable crop protection and the challenges.
Xuexia Liu, Zhenhui Zhong
wiley   +1 more source

Communication is key: combinatorial phosphorylation and functional cross-talk in the RNA polymerase II CTD code. [PDF]

Biochem Soc Trans
Zhang YJ, Ramsey E.
europepmc   +1 more source

A Global View of DNA-Packing Proteins Cracks the Histone Code

PLoS Biology, 2005
doaj  

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Histone isoforms and the oncohistone code

Current Opinion in Genetics & Development, 2021
Recent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene families. There is heterogeneity among these genes at the level of the underlying sequence, the amino acid composition of the encoded
Andrew Flaus, Jessica A Downs, Tom Owen-Hughes   +2 more
openaire   +3 more sources