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Cracking the Enigmatic Linker Histone Code
Journal of Biochemistry, 2007Recently, the existence of a 'histone code' has been proposed to explain the link between the covalent chemical modification of histone proteins and the epigenetic regulation of gene activity. Although the role of the four 'core' histones has been extensively studied, little is known about the involvement of the linker histone, histone H1 and its ...
James S, Godde, Kiyoe, Ura
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Science, 2016
Epigenetics Regulatory information is stored both in DNA sequences and in the chromatin proteins that package the genome. The covalent modification of histones plays a critical role in signaling whether a gene or genomic region should be active or inactive. Shema et al.
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Epigenetics Regulatory information is stored both in DNA sequences and in the chromatin proteins that package the genome. The covalent modification of histones plays a critical role in signaling whether a gene or genomic region should be active or inactive. Shema et al.
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[The epigenetic code of histones].
Medecine sciences : M/S, 2003It has become clear that post-translational modifications of histones are key players in the mechanisms of transcriptional regulation. There are 4 major types of histone modifications: acetylation, methylation, phosphorylation and ubiquitinylation. Different combinations of these modifications would form an epigenetic code which, once read by specific ...
Nicolas, Lacoste, Jacques, Côté
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