Results 171 to 180 of about 137,192 (357)

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor [PDF]

, 2023
Canrong Li, Yingyi Ouyang, Chuxin Lu, Feng-Zhi Chen, Yuguo Yi, Shujun Peng, Yifan Wang, Xinyu Chen, Xiao Yan, Shuiming Li, Lin Feng, Xiaoduo Xie   +11 more
openalex   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Histone deacetylases repress the accumulation of licochalcone A by inhibiting the expression of flavonoid biosynthetic pathway-related genes in licorice (Glycyrrhiza inflata)

Molecular Horticulture
Histone deacetylases (HDACs) play a crucial role in regulating plant growth, stress responses, and specialized metabolism. Licorice, utilized as both food and herbal medicine for millennia, includes Glycyrrhiza inflata as one of its primary medicinal ...
Jiangyi Zeng, Xiaoling Ma, Yuping Li, Lijun Zhou, Jingxian Fu, Hongxia Wang, Yongliang Liu, Ling Yuan, Ying Wang, Yongqing Li   +9 more
doaj   +1 more source

EXTH-11. HISTONE DEACETYLASE 6 (HDAC6) INHIBITORS RETARD CELL PROLIFERATION AND INDUCE ROBUST CELL DEATH IN GLIOBLASTOMA (GBM) CELLS AND GBM SPHEROIDS CONTAINING STEM CELLS [PDF]

, 2016
M. Reza Saadatzadeh
openalex   +1 more source

Data from OSU-HDAC42, a Histone Deacetylase Inhibitor, Blocks Prostate Tumor Progression in the Transgenic Adenocarcinoma of the Mouse Prostate Model

, 2023
Aaron M. Sargeant, Robert C. Rengel, Samuel K. Kulp, Russell D. Klein, Steven K. Clinton, Yu-Chieh Wang, Ching‐Shih Chen   +6 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Targeting euchromatic histone lysine methyltransferases sensitizes colorectal cancer to histone deacetylase inhibitors [PDF]

, 2022
L Bamberg, Florian Heigwer, Anna Maxi Wandmacher, Ambika Singh, Johannes Betge, Niklas Rindtorff, Johannes Werner, Julia Josten, Olga Skabkina, Isabel Hinsenkamp, Gerrit Erdmann, Christoph Röcken, Matthias Ebert, Elke Burgermeister, Tianzuo Zhan, Michael Boutros   +15 more
openalex   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

In vivoBiological Activity of the Histone Deacetylase Inhibitor LAQ824 Is detectable with 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography [PDF]

, 2006
Julius Leyton, John P. Alao, Marco Da Costa, Alexandra Stavropoulou, John Latigo, Meg Perumal, Radhakrishna G. Pillai, Qimin He, Peter Atadja, Eric W.‐F. Lam, Paul Workman, David M. Vigushin, Eric O. Aboagye   +12 more
openalex   +1 more source

Protective Effects of Auricularia auricula Polysaccharides on Acute Lung Injury by Regulating Intestinal Flora and Metabolism

Food Frontiers, EarlyView.
Auricularia auricula polysaccharides (AAP; 100, 200, and 400 mg/kg) protect against acute lung injury (ALI) by dose‐dependently remodeling the gut microbiota and modulating associated metabolic pathways via the gut‐lung axis, thereby enhancing pulmonary anti‐inflammatory and antioxidant capacity to ultimately prevent tissue damage.
Haili Niu, Fangjia Zhao, Qi Wang, Min Li, Yuan Li, Ivan Kurtovic, Zitong Zhang, Yahong Yuan, Tianli Yue   +8 more
wiley   +1 more source