HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors [PDF]
Frontiers in Physiology, 2018 Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini +5 more
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A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma [PDF]
Frontiers in Oncology, 2023 This review aims to summarize the putative role of histone deacetylases (HDACs) in rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by elucidating and highlighting known oncogenic pathways, mechanisms of resistance, and the ...
Omar Selim +7 more
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Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]
Scientific Reports, 2017 Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Brice J. Albert +8 more
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Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B [PDF]
Molecular Cancer, 2006 Background In eukaryotic cells, the genomic DNA is packed with histones to form the nucleosome and chromatin structure. Reversible acetylation of the histone tails plays an important role in the control of specific gene expression.
Li Qiao +3 more
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New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer [PDF]
Journal of Hematology & Oncology, 2009 DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders.
Ma Yuehua, Cang Shundong, Liu Delong
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Role of histone deacetylase inhibitors in non-neoplastic diseases [PDF]
HeliyonBackground: Epigenetic dysregulation has been implicated in the development and progression of a variety of human diseases, but epigenetic changes are reversible, and epigenetic enzymes and regulatory proteins can be targeted using small molecules ...
Chunxiao Zhou +7 more
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Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectives [PDF]
Experimental Hematology & OncologyHistone deacetylase inhibitors (HDACis) are a significant category of pharmaceuticals that have developed in the past two decades to treat multiple myeloma. Four drugs in this category have received approval from the U.S.
Jingjing Pu +6 more
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Histone deacetylase inhibitors for leukemia treatment: current status and future directions [PDF]
European Journal of Medical ResearchLeukemia remains a major therapeutic challenge in clinical oncology. Despite significant advancements in treatment modalities, leukemia remains a significant cause of morbidity and mortality worldwide, as the current conventional therapies are ...
Mohammad-Salar Hosseini +4 more
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Current treatment strategies targeting histone deacetylase inhibitors in acute lymphocytic leukemia: a systematic review [PDF]
Frontiers in OncologyAcute lymphocytic leukemia is a hematological malignancy that primarily affects children. Long-term chemotherapy is effective, but always causes different toxic side effects.
Yingjun Zhang +19 more
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Histone deacetylase inhibitors
Journal of Education, Health and Sport, 2020 The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran +2 more
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