Results 161 to 170 of about 112,513 (255)

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

High-throughput screening identifies the activity of histone deacetylase inhibitors in patient-derived models of soft tissue sarcoma. [PDF]

Cancer Biol Ther
Danks MR, Manasterski PJ, Beetham H, Dawson JC, Elliott RJR, Culley J, Krishna R, Muir M, Thomson JP, Oswald AJ, Ewing A, Kerrison WGJ, Huang PH, Nixon I, Carragher NO, Brunton VG.   +15 more
europepmc   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Correction: Histone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1. [PDF]

Sci Rep
Wang D, Yang Y, Cao Y, Meng M, Wang X, Zhang Z, Fu W, Duan S, Tang L.   +8 more
europepmc   +1 more source

Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites. [PDF]

Int J Parasitol Drugs Drug Resist
Dawood WA, Fisher GM, Kremeyer J, Fischer F, Home JL, Goodman CD, Lam KS, Maier AG, Kurz T, Andrews KT.   +9 more
europepmc   +1 more source

Histone Deacetylase Inhibitors orchestrate epigenetic signalling and alter the nucleoporins and nuclear envelope in cervical cancer. [PDF]

Transl Oncol
Rani H, Ganai SA, Mahadevan V.
europepmc   +1 more source

The effect of histone deacetylase inhibitors on the efficiency of the CRISPR/Cas9 system. [PDF]

Biochem Biophys Rep, 2023
Björnson Y, Huang CY, Rollins JL, Castañeda G, Kaur N, Yamamoto E, Johnston JM.   +6 more
europepmc   +1 more source

Histone Deacetylase Inhibitors Promote the Anticancer Activity of Cisplatin: Mechanisms and Potential. [PDF]

Pharmaceuticals (Basel)
Zhou Y, Luo Q, Gu L, Tian X, Zhao Y, Zhang Y, Wang F.   +6 more
europepmc   +1 more source

Screening anticancer peptides performance in organotypic prostate tumor‐stroma 3D models

International Journal of Cancer, EarlyView.
What's New? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Bárbara Matos, Maria V. Monteiro, Matilde R. Lagarto, John Howl, Carmen Jerónimo, Vítor M. Gaspar, João F. Mano, Margarida Fardilha   +7 more
wiley   +1 more source

Synthesis, In Silico, and Biological Evaluation of Non-Hydroxamate Benzoic Acid-Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi). [PDF]

Chem Biodivers
Al Rahim NAA, Mahmood AAR, Tahtamouni LH, Bawadi RM, Almasri AY, Hamad MA, Hussein NA, Yasin SR, Saleh AM.   +8 more
europepmc   +1 more source