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Histone Demethylases in Colon Cancer [PDF]
Current Colorectal Cancer Reports, 2014 Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul +5 more
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The emerging role of KDM5A in human cancer
Journal of Hematology & Oncology, 2021 Histone methylation is a key posttranslational modification of chromatin, and its dysregulation affects a wide array of nuclear activities including the maintenance of genome integrity, transcriptional regulation, and epigenetic inheritance.
Guan-Jun Yang +7 more
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The Discovery of Histone Demethylases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
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In Vitro Histone Demethylase Assay [PDF]
Cold Spring Harbor Protocols, 2010 INTRODUCTIONPost-translational modifications of histones play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues, and methylation status defines the epigenetic program of a cell by determining chromatin structure and thereby regulating DNA-dependent ...
Yu-ichi, Tsukada, Keiichi I, Nakayama
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G3: Genes, Genomes, Genetics, 2016 Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity.
Mengying Liu +2 more
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Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A
Frontiers in Pharmacology, 2022 Epigenetics has emerged as a prime focus area in the field of cancer research. Lysine-specific demethylase 1A (LSD1), the first discovered histone demethylase, is mainly responsible for catalysing demethylation of histone 3 lysine 4 (H3K4) and H3K9 to ...
Chao Yang +5 more
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Human Histone Demethylase LSD1 Reads the Histone Code [PDF]
Journal of Biological Chemistry, 2005 Human histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. The N-terminal tail of H3 is subject to various covalent modifications, and a fundamental question in LSD1 biology is how these epigenetic marks affect the demethylase activity.
F. Forneris +4 more
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LSD1: Expanding Functions in Stem Cells and Differentiation
Cells, 2021 Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that
Carlos Martinez-Gamero +2 more
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Journal of Pharmacological Sciences, 2011 The hypoxia response regulated primarily by hypoxia-inducible factor (HIF) influences metabolism, cell survival, and angiogenesis to maintain biological homeostasis.
Imari Mimura +4 more
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BMC Evolutionary Biology, 2008 Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Zhou Xiaofan, Ma Hong
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