Results 141 to 150 of about 197,157 (312)
Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila [PDF]
, 2017 Jumonji (JmjC) domain proteins influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome.
Buszczak, Michael +6 more
core +1 more source
Frontiers in Plant Science, 2015 Seed dormancy controls germination and plays a critical role in regulating the beginning of the life cycle of plants. Seed dormancy is established and maintained during seed maturation and is gradually broken during dry storage (after-ripening).
Minglei Zhao +3 more
semanticscholar +1 more source
Ibrain, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley +1 more source
Cell Reports, 2018 Summary: How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical ...
Jessica Camacho +8 more
doaj +1 more source
Undercover: Gene control by metabolites and metabolic enzymes [PDF]
, 2016 To make the appropriate developmental decisions or maintain homeostasis, cells and organisms must coordinate the expression of their genome and metabolic state. However, the molecular mechanisms that relay environmental cues such as nutrient availability
Knaap, J.A. (Jan) van der +1 more
core +2 more sources
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
The Discovery of Histone Demethylases [PDF]
Cold Spring Harb Perspect Biol, 2013 Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
europepmc +5 more sources
Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series) [PDF]
, 2014 Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action.
Handy, Diane E., Loscalzo, Joseph
core +1 more source
JmjC Domain-containing Histone Demethylase Gene Family in Chinese Cabbage: Genome-wide Identification and Expressional Profiling [PDF]
, 2023 Fengrui Yin +8 more
openalex +1 more source
Epigenetic regulation by histone demethylases in hypoxia.
Epigenomics, 2015 The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor (HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the 2-oxoglutarate (2OG) dependent oxygenase family.
R. L. Hancock +4 more
semanticscholar +1 more source