Results 11 to 20 of about 18,790 (139)
The emerging role of histone demethylases in renal cell carcinoma [PDF]
Journal of Kidney Cancer and VHL, 2017 Renal cell carcinoma (RCC), the most common kidney cancer, is responsible for more than 100,000 deaths per year worldwide. The molecular mechanism of RCC is poorly understood.
Xiaoqiang Guo, Qiaoxia Zhang
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Relationship between histone demethylase LSD family and development and prognosis of gastric cancer
Frontiers in Immunology, 2023 Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong +8 more
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Cells, 2022 Epigenetic regulation of gene expression is crucial to the determination of cell fate in development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of proteins, acting antagonistically as complexes, play a major role in this ...
Joyce Taylor-Papadimitriou +1 more
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Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. [PDF]
PLoS ONE, 2012 Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes.
Chibawanye I Ene +18 more
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Biomolecules, 2021 Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells.
Hans Felix Staehle +2 more
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eLife, 2017 Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors.
Ryan Janke +2 more
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Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. [PDF]
PLoS ONE, 2016 Histone demethylases have recently gained interest as potential targets in cancer treatment and several histone demethylases have been implicated in the DNA damage response.
Corina Penterling +15 more
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SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
Nature Communications, 2021 SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so that
Octavio A. Romero +19 more
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Cells, 2022 Epigenetic aberrations, associated with altered DNA methylation profiles and global changes in the level of histone modifications, are commonly detected in head and neck squamous cell carcinomas (HNSCC).
Dawid Dorna, Jarosław Paluszczak
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Targeting epigenetic regulators to overcome drug resistance in cancers
Signal Transduction and Targeted Therapy, 2023 Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
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