Results 11 to 20 of about 197,157 (312)

Histone demethylases in autophagy and inflammation [PDF]

Cell Communication and Signaling
Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase,
Yaoyao Ma, Wenting Lv, Yi Guo, Tong Yin, Yujie Bai, Ziqi Liu, Chao Chen, WenjuanYang, Jiayi Feng, Wenbin Qian, Ruiling Tang, Yanting Su, Shigang Shan, Huifen Dong, Yongfen Bao, Lihua Qu   +15 more
doaj   +4 more sources

Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities [PDF]

Current Issues in Molecular Biology
Histone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the role and therapeutic potential of HDM in CRC.
Yuanbin Liu, Min Huang, Xia Tian, Xiaodong Huang   +3 more
doaj   +2 more sources

Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases

eLife, 2017
Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors.
Ryan Janke, Anthony T Iavarone, Jasper Rine   +2 more
doaj   +2 more sources

Histone Demethylases as Counterbalance to H3K27me3 Silencing in Plants [PDF]

iScience, 2020
Summary: The universal importance of epigenetic regulation has become explicit over the last decade. There is now a detailed understanding of the molecular signatures and chromatin-modifying enzymes determining epigenetic regulation.
Pedro Crevillén
doaj   +2 more sources

Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases. [PDF]

ChemMedChem, 2019
Human histone demethylases are known to play an important role in the development of several tumor types. Consequently, they have emerged as important medical targets for the treatment of human cancer.
Małecki PH, Rüger N, Roatsch M, Krylova O, Link A, Jung M, Heinemann U, Weiss MS.   +7 more
europepmc   +2 more sources

The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes

Frontiers in Cell and Developmental Biology, 2022
Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed, Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Hani Choudhry, Firoz Ahmed, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan, Mohammad Imran Khan   +9 more
doaj   +2 more sources

Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells. [PDF]

Cancers (Basel), 2019
Lysine histone demethylases (KDMs) are considered potential therapeutic targets in several tumors, including glioblastoma (GB). In particular, KDM5A is involved in the acquisition of temozolomide (TMZ) resistance in adult GB cells and UDX/KDM6B regulates
Romani M, Daga A, Forlani A, Pistillo MP, Banelli B.   +4 more
europepmc   +2 more sources

JARID1 Histone Demethylases: Emerging Targets in Cancer. [PDF]

Trends Cancer, 2017
JARID1 proteins are histone demethylases that both regulate normal cell fates during development and contribute to the epigenetic plasticity that underlies malignant transformation. This H3K4 demethylase family participates in multiple repressive transcriptional complexes at promoters and has broader regulatory effects on chromatin that remain ill ...
Harmeyer KM, Facompre ND, Herlyn M, Basu D.   +3 more
europepmc   +5 more sources

The Four FAD-Dependent Histone Demethylases of Arabidopsis Are Differently Involved in the Control of Flowering Time. [PDF]

Front Plant Sci, 2019
In Arabidopsis thaliana, four FAD-dependent lysine-specific histone demethylases (LDL1, LDL2, LDL3, and FLD) are present, bearing both a SWIRM and an amine oxidase domain.
Martignago D, Bernardini B, Polticelli F, Salvi D, Cona A, Angelini R, Tavladoraki P.   +6 more
europepmc   +2 more sources

KDM5 histone demethylases repress immune response via suppression of STING. [PDF]

PLoS Biol, 2018
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer.
Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q.   +23 more
europepmc   +2 more sources