Results 171 to 180 of about 60,846 (261)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Gene up-regulation by DNA demethylation in 35S-gshI-transgenic poplars (Populus x canescens) [PDF]

, 2008
Gene expression levels of transgene 35S-gshI (γ-glutamylcysteine synthetase) cloned from E. coli, and the endogenous gene gsh1 of poplar (Populus x canescens) were upregulated by the DNA demethylating agent DHAC (5,6-dihydro-5'-azacytidine ...
Bittsánszky, András, Gullner, Gábor, Gyulai, Gábor, Heszky, László, Kiss, J., Kőmíves, Tamás, Szabó, Zoltán, Tóth, Z.   +7 more
core  

Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells. [PDF]

Blood Sci, 2020
Sarma P, Plas DR.
europepmc   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A [PDF]

, 2011
Toru Sengoku, Shigeyuki Yokoyama
openalex   +1 more source

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

, 2015
Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, Xinjian Li, Rui Liu, Yan Xia, Qianming Chen, Guang Peng, Shiaw‐Yih Lin, Zhimin Lu   +10 more
openalex   +1 more source

Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation

Signal Transduction and Targeted Therapy
Epstein-Barr virus (EBV) is a significant epigenetic driver in the development of epithelial-origin nasopharyngeal carcinoma (NPC) and gastric cancer (GC), which together represent 80% of EBV-associated malignancies.
Ya-Qing Zhou, Jia-Xin Jiang, Shuai He, Yi-Qi Li, Xi-Xi Cheng, Shu-Qiang Liu, Pan-Pan Wei, Xin-Yuan Guan, Choon Kiat Ong, Vivien Ya-Fan Wang, Chun-Ling Luo, Jin-Xin Bei   +11 more
doaj   +1 more source

Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation [PDF]

Chloé I. Charendoff, Félix V. Louchez, Yongzheng Wu, Lee Dolat, Guillaume Velasco, Stéphanie Perrinet, Adrián Gabriel Torres, Laure Blanchet, Magalie Duchateau, Quentin Giai Gianetto, Mariette Matondo, Laurence Del Maestro, Slimane Ait‐Si‐Ali, Frédéric Bonhomme, Gaël A. Millot, Lluı́s Ribas de Pouplana, Elisabeth D. Martínez, Raphael H. Valdivia, Agathe Subtil, Agathe Subtil   +19 more
openalex   +1 more source

Chemical and biochemical approaches in the study of histone methylation and demethylation

, 2012
Keqin Kathy Li, Cheng Luo, Dongxia Wang, Hualiang Jiang, Y. George Zheng   +4 more
openalex   +2 more sources