Results 1 to 10 of about 196,399 (287)
A vector system encoding histone H3 mutants facilitates manipulations of the neuronal epigenome [PDF]
Scientific ReportsThe differentiation of developmental cell lineages is associated with genome-wide modifications in histone H3 methylation. However, the causal role of histone H3 methylation in transcriptional regulation and cell differentiation has been difficult to ...
Sophie Warren +3 more
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Fujita Medical Journal, 2023 Objectives: Damage associated molecular patterns (DAMPs) levels are associated with sepsis severity and prognosis. Histone and high mobility group box 1 (HMGB1) levels are also potential indicators of prognosis.
Ken Sawada +8 more
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Apoptotic phosphorylation of histone H3 on Ser-10 by protein kinase Cδ. [PDF]
PLoS ONE, 2012 Phosphorylation of histone H3 on Ser-10 is regarded as an epigenetic mitotic marker and is tightly correlated with chromosome condensation during both mitosis and meiosis.
Choon-Ho Park, Kyong-Tai Kim
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Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. [PDF]
PLoS Biology, 2005 A major focus of current research into gene induction relates to chromatin and nucleosomal regulation, especially the significance of multiple histone modifications such as phosphorylation, acetylation, and methylation during this process.
Catherine A Hazzalin, Louis C Mahadevan
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases
Endocrine Journal, 2023 Autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are organ-specific autoimmune diseases. Histone acetylation, especially that of histone H3, is an epigenetic mechanism that regulates gene expression and is ...
Emi Haga +8 more
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Extracellular histone H3 facilitates ferroptosis in sepsis through ROS/JNK pathway
Immunity, Inflammation and Disease, 2023 Introduction Previous evidence realized the critical role of histone in disease control. The anti‐inflammatory function of estradiol (E2) in sepsis has been documented.
Zhijun Han +5 more
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Nanoarchaeal Origin of Histone H3? [PDF]
Journal of Bacteriology, 2009 ABSTRACTNEQ288, one of two archaeal histones inNanoarchaeum equitans, has a unique four-residue insertion that closely resembles an insertion in the eukaryotic histone H3 lineage. NEQ288 bound DNA but did not compact DNA in vitro in the absence of NEQ348, the secondN. equitansarchaeal histone.
Ulrike, Friedrich-Jahn +4 more
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JAK2 Gets Histone H3 Rolling [PDF]
Cancer Cell, 2009 Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription.
Sattler, Martin, Griffin, James D.
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Histone H3 Mutations in Cancer [PDF]
Current Pharmacology Reports, 2018 Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in cancers. More recently, recurrent histone mutations have been identified in multiple cancers and have been shown to impede histone methylation ...
Wan, Yi Ching Esther +2 more
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Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M. +6 more
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