Results 171 to 180 of about 181,554 (237)

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

Cell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li, Jingya Zhang, Xu Wang, Xinru Wang, Yuyu Song, Xinyue Song, Xiuli Wang, Weiwei Cao, Chong Zhao, Jing Qi, Xiaodong Zheng, Yan Xing   +11 more
wiley   +1 more source

Calcineurin/NFATc1 pathway represses cellular cytotoxicity by modulating histone H3 expression. [PDF]

Sci Rep
Sato Y, Habara M, Hanaki S, Sharif J, Tomiyasu H, Miki Y, Shimada M.   +6 more
europepmc   +1 more source

Testis‐Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis

Cell Proliferation, EarlyView.
PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang, Kailun Fang, Yongliang Shang, Xu Zhou, Qiqi Shao, Si Li, Ping Wang, Charlie Degui Chen, Liangran Zhang, Shunxin Wang   +9 more
wiley   +1 more source

Integrative multi-omics analysis of radionuclide-induced intestinal injury reveals the radioprotective role of L-citrulline through histone H3-mediated Cxcl3. [PDF]

J Transl Med
Yang P, Bai H, Yan T, Xu X, Tang X, Song B, Liu Y, Lu Y, Liu P, Tu W, Shi Y, Zhang S.   +11 more
europepmc   +1 more source

Stroke‐Homing Peptide‐DNase1 Alleviates Intestinal Ischemia Reperfusion Injury by Selectively Degrading Neutrophil Extracellular Traps

Cell Proliferation, EarlyView.
SHp‐DNase1 combined with CRO inhibits NETs to alleviate intestinal IRI ABSTRACT Neutrophil extracellular traps (NETs) act as a vital first line of defence against tissue damage and pathogens, playing a significant role in improving diseases such as intestinal ischemia reperfusion injury (IRI).
Tingting Liu, Xinrong Lv, Qingshan Xu, Xiuting Qi, Shenghui Qiu, Yaqi Luan, Na Shen, Jing Cheng, Lan Jin, Tian Tian, Wentao Liu, Lai Jin, Zhongzhi Jia   +12 more
wiley   +1 more source

Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression. [PDF]

Genes Dev
Anyetei-Anum CS, Leatham-Jensen MP, Fox GC, Smith BR, Chirasani VR, Krajewski K, Strahl BD, Dowen JM, Matera AG, Duronio RJ, McKay DJ.   +10 more
europepmc   +1 more source

Ezh2 Regulates Early Astrocyte Morphogenesis and Influences the Coverage of Astrocytic Endfeet on the Vasculature

Cell Proliferation, EarlyView.
Ezh2‐deficient astrocytes showed morphologically more slender but sparse dendrites, resulting in reduced endfoot coverage and also causing disruption of the blood–brain barrier. ABSTRACT Astrocytes are crucial for central nervous system (CNS) development and function, with their differentiation being stringently controlled by epigenetic mechanisms ...
Xinghua Zhao, Mengtian Zhang, WenZheng Zou, Chenxiao Li, Shukui Zhang, Yuqing Lv, Libo Su, Fen Ji, Jianwei Jiao, Yufei Gao   +9 more
wiley   +1 more source

Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K. [PDF]

Genes Cells
Kimura T, Hirai S, Kujirai T, Fujita R, Ogasawara M, Ehara H, Sekine SI, Takizawa Y, Kurumizaka H.   +8 more
europepmc   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Histone H3 trimethylation on lysine 27 immunostaining pattern in DICER1-associated tumors. [PDF]

Transl Pediatr
Alturkustani M, Yang B, Bockoven C, Mahabir R, Shillingford N, Schmidt RJ, Zhou S, Warren M, Parham DM, Pawel B, Wang LL.   +10 more
europepmc   +1 more source