Results 181 to 190 of about 181,554 (237)

RNF187 Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through WDR77 Polyubiquitination

Cell Proliferation, EarlyView.
RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu, Xiaoxue Xi, Bing Jiang, Kehan Wang, Tiantian Wu, Xia Chen, Yueshuai Guo, Tao Zhou, Xiaoyan Huang, Jun Yu, Tingting Gao, Yibo Wu, Bo Zheng   +12 more
wiley   +1 more source

Binding to nucleosome poises human SIRT6 for histone H3 deacetylation. [PDF]

Elife
Smirnova E, Bignon E, Schultz P, Papai G, Ben Shem A.   +4 more
europepmc   +1 more source

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Cell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang, Xinle Lai, Fangxuan Lin, Nan Shi, Xinya Xu, Heng Wang, Xiaotian Li, Dan Shen, Haimo Qian, Xin Jin, Jiayi Chen, Zhongwei Huang, Xing Duan, Qin Zhang   +13 more
wiley   +1 more source

Author Correction: Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation. [PDF]

Nat Commun
Nacev BA, Dabas Y, Paul MR, Pacheco C, Mitchener M, Perez Y, Fang Y, Soshnev AA, Barrows D, Carroll T, Socci ND, St Jean SC, Tiwari S, Gruss MJ, Monette S, Tap WD, Garcia BA, Muir T, Allis CD.   +18 more
europepmc   +1 more source

TREM2 Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization‐Mediated Autophagy

Cell Proliferation, EarlyView.
TREM2 exacerbates spinal cord injury by inhibiting TFEB nuclear translocation, aggravating lysosomal membrane permeabilisation and consequently suppressing autophagy. ABSTRACT Microglia, considered as the main immune responder, play an important role in regulating neuroinflammation in central nervous system (CNS) disorders. Our previous work found that
Tianlun Zhao, Jiawei Di, Yu Kang, Haojie Zhang, Senyu Yao, Bin Liu, Limin Rong   +6 more
wiley   +1 more source

A circular engineered sortase for interrogating histone H3 in chromatin

Whedon SD, Lee K, Wang ZA, Zahn E, Lu C, Yapa-Abeywardana M, Fairall L, Nam E, Dubois-Coyne S, De Ioannes P, Sheng X, Andrei A, Lundberg E, Jiang J, Armache K, Zhao Y, Schwabe JWR, Wu M, Garcia BA, Cole PA.   +19 more
europepmc   +1 more source

The Significance of Modified Histone H3 in Epithelial Dysplasia and Oral Cancer. [PDF]

Int Dent J
Tachaveeraphong W, Phattarataratip E.
europepmc   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Research Advances of the Autophagy‐Regulated Radiosensitivity

Cell Proliferation, EarlyView.
Autophagy plays a dual role in regulating cellular radiosensitivity in radiotherapy (RT). We discuss the mechanisms by which autophagy promotes survival and growthsuppression by modulating radiosensitivity. It also outlines some frontier autophagy‐targeted radiotherapies. ABSTRACT Autophagy is an evolutionarily conserved process of cell self‐catabolism
Hanyue Liu, Yanlan Xiao, Chuhao Dai, Keyu Chen, Xinyi Xu, Jianming Cai, Xuguang Hu, Jiaming Guo   +7 more
wiley   +1 more source

Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition. [PDF]

Elife
Pepin AS, Jazwiec PA, Dumeaux V, Sloboda DM, Kimmins S.   +4 more
europepmc   +1 more source