Results 201 to 210 of about 181,554 (237)

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

Epithelial cells maintain memory of prior infection with Streptococcus pneumoniae through di-methylation of histone H3. [PDF]

Nat Commun
Chevalier C, Chica C, Matheau J, Pain A, Connor MG, Hamon MA.   +5 more
europepmc   +1 more source

Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation

, 2023
Lee SC, Adams DW, Ipsaro JJ, Cahn J, Lynn J, Kim H, Berube B, Major V, Calarco JP, LeBlanc C, Bhattacharjee S, Ramu U, Grimanelli D, Jacob Y, Voigt P, Joshua-Tor L, Martienssen RA.   +16 more
europepmc   +1 more source

N‐acetylglucosamine sensing in the filamentous soil fungus Trichoderma reesei

The FEBS Journal, EarlyView.
N‐acetylglucosamine (GlcNAc) is involved in diverse signaling pathways in dimorphic yeasts and bacteria, including virulence and cell death. Here, we investigated GlcNAc sensing in Trichoderma reesei. GlcNAc signaling influences around 2100 genes in this filamentous soil fungus.
Sadia Fida Ullah, Mislav Oreb, Eckhard Boles, Vaibhav Srivastava, Verena Seidl‐Seiboth, Bernhard Seiboth, Lisa Kappel   +6 more
wiley   +1 more source

Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation. [PDF]

J Inflamm (Lond)
Piatek P, Namiecinska M, Lewkowicz N, Kulińska-Michalska M, Jabłonowski Z, Matysiak M, Michlewska S, Wieczorek M, Lewkowicz P.   +8 more
europepmc   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

Neutrophil Extracellular Traps Are Widely Distributed Across Lesional and Perilesional Hidradenitis Suppurativa Skin, and Elevated Serum NET Markers Associate With Moderate to Severe HS Disease

International Journal of Dermatology, EarlyView.
Increased NET markers are detected in HS skin and blood. Neutrophils are scarce in healthy skin but infiltrate lesions of hidradenitis suppurativa (HS) patients. Activated neutrophils release proinflammatory neutrophil extracellular traps (NETs). The NET marker CitH3 was widely distributed across both lesional and perilesional regions of HS skin but ...
Stephanie C. M. van Dalen, Josephine W. J. Stein, Tirza Bruurmijn, Martyn L. Foster, Renato G. S. Chirivi, Maarten van der Linden, Helmuth van Es, Jacek C. Szepietowski, Piotr K. Krajewski, Kelsey R. van Straalen, Errol P. Prens, John R. Ingram, Eric Meldrum   +12 more
wiley   +1 more source

Investigation of Ki67 and Phospho-Histone H3 Expressions in Urothelial Carcinoma of the Bladder by Immunohistochemical Method. [PDF]

Cureus
Yüceer RO, Başpınar Ş.
europepmc   +1 more source

Sex‐dimorphic gene regulation in murine macrophages across niches

Immunology &Cell Biology, EarlyView.
In this study, we perform a meta‐analysis of new and publicly available RNA‐seq datasets from male and female mouse macrophages across eight niches to identify conserved sex‐dimorphic gene expression patterns. We found that three sex chromosome‐linked genes are always differentially expressed between males and females: Ddx3y, Eif2s3y and Xist. However,
Cassandra J McGill, Olivia S White, Ryan J Lu, Nirmal K Sampathkumar, Bérénice A Benayoun   +4 more
wiley   +1 more source

Oxidative stress contributes to hypermethylation of Histone H3 lysine 9 in placental trophoblasts from preeclamptic pregnancies. [PDF]

Front Endocrinol (Lausanne)
Gu Y, Cooper D, Lewis DF, Zoorob D, Wang Y.   +4 more
europepmc   +1 more source