Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork [PDF]
, 2015 International audienceMCM2 is a subunit of the replicative helicase machinery shown to interact with histones H3 and H4 during the replication process through its N-terminal domain.
Almouzni, Geneviève +13 more
core +10 more sources
Investigation of in vitro histone H3 glycosylation using H3 tail peptides
Scientific Reports, 2022 Posttranslational modifications (PTMs) on histone tails regulate eukaryotic gene expression by impacting the chromatin structure and by modulating interactions with other cellular proteins.
Jona Merx +10 more
doaj +1 more source
Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling [PDF]
, 2009 The (H3-H4)2 histone tetramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disassembly and positioning of nucleosomes.
Bowman, A. +4 more
core +5 more sources
The Histone Deacetylase Complex (HDC) 1 protein of Arabidopsis thaliana has the capacity to interact with multiple proteins including histone 3-binding proteins and histone 1 variants [PDF]
, 2016 Intrinsically disordered proteins can adopt multiple conformations thereby enabling interaction with a wide variety of partners. They often serve as hubs in protein interaction networks. We have previously shown that the Histone Deacetylase Complex (HDC)
Amtmann, Anna +6 more
core +1 more source
Extracellular histone H3 [PDF]
, 2020 This research was aimed at studying histone proteins in tissue damage. An important finding was that the more histones were present in donor kidneys during machine preservation, the poorer the organ function after transplantation. The amount of histones seems to be related to the amount of kidney damage.
openaire +1 more source
Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals
Cells, 2020 The systematic mutation of histone 3 (H3) genes in model organisms has proven to be a valuable tool to distinguish the functional role of histone residues.
Matteo Trovato +3 more
doaj +1 more source
PRB1 is required for clipping of the histone H3 N terminal tail in Saccharomyces cerevisiae.
PLoS ONE, 2014 Cathepsin L, a lysosomal protein in mouse embryonic stem cells has been shown to clip the histone H3 N- terminus, an activity associated with gene activity during mouse cell development.
Yong Xue +4 more
doaj +1 more source
Evidence for gene-specific rather than transcription rate-dependent histone H3 exchange in yeast coding regions. [PDF]
PLoS Computational Biology, 2009 In eukaryotic organisms, histones are dynamically exchanged independently of DNA replication. Recent reports show that different coding regions differ in their amount of replication-independent histone H3 exchange.
Irit Gat-Viks, Martin Vingron
doaj +1 more source
Characteristic H3 N-tail dynamics in the nucleosome core particle, nucleosome, and chromatosome
iScience, 2022 Summary: The nucleosome core particle (NCP) comprises a histone octamer, wrapped around by ∼146-bp DNA, while the nucleosome additionally contains linker DNA.
Ayako Furukawa +7 more
doaj +1 more source
The histone chaperone Vps75 forms multiple oligomeric assemblies capable of mediating exchange between histone H3–H4 tetramers and Asf1–H3–H4 complexes [PDF]
, 2016 Wellcome Trust [094090, 097945, 099149]; Medical Research Council [G1100021]. Funding for open access charge: Wellcome Trust.Vps75 is a histone chaperone that has been historically characterized as homodimer by X-ray crystallography.
Angus Lamond +11 more
core +3 more sources