Results 61 to 70 of about 181,554 (237)

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Histone H3-K56 Acetylation Is Catalyzed by Histone Chaperone-Dependent Complexes [PDF]

Molecular Cell, 2007
Acetylation of histone H3 on lysine 56 occurs during mitotic and meiotic S phase in fungal species. This acetylation blocks a direct electrostatic interaction between histone H3 and nucleosomal DNA, and the absence of this modification is associated with extreme sensitivity to genotoxic agents.
Tsubota, Toshiaki, Berndsen, Christopher E., Erkmann, Judith A., Smith, Corey Lewis, Yang, Lanhao, Freitas, Michael A., Denu, John M., Kaufman, Paul D.   +7 more
openaire   +4 more sources

Role of histone modifications in marking and activating genes through mitosis [PDF]

, 2015
The global inhibition of transcription at the mitotic phase of the cell cycle occurs together with the general displacement of transcription factors from the mitotic chromatin.
Martínez-Balbás, Marian, Sánchez-Molina, Sara, Valls, Ester   +2 more
core   +2 more sources

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Phosphorylation of histone H3 in plants—A dynamic affair

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2007
Histones are the main protein components of chromatin: they undergo extensive post-translational modifications, particularly acetylation, methylation, phosphorylation, ubiquitination and ADP-ribosylation which modify the structural/functional properties of chromatin.
Houben, Andreas, Demidov, Dmitri, Caperta, A., Karimi, Raheleh, Agueci, Francesco, Vlasenko, Liudmila   +5 more
openaire   +4 more sources

Gcn5p is involved in the acetylation of histone H3 in nucleosomes [PDF]

FEBS Letters, 1997
© 1997 Federation of European Biochemical Societies.
Mercè Pamblanco, Ana Belén Ruiz-García, Ramon Sendra, Vicente Tordera   +3 more
openaire   +3 more sources

Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast [PDF]

, 2012
The inheritance of the histone H3 variant CENP-A in nucleosomes at centromeres following DNA replication is mediated by an epigenetic mechanism. To understand the process of epigenetic inheritance, or propagation of histones and histone variants, as ...
Allshire, Robin C, Berger, Harald, Carr, Antony M, Dunne, Paul D, Endesfelder, Ulrike, Heilemann, Mike, Klenerman, David, Lando, David, Laue, Ernest D, McColl, James, Sauer, Markus, Subramanian, Lakxmi   +11 more
core   +2 more sources

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Semi-Synthesis to Examine the Role of Phosphorylation of Histone H3 at T118 [PDF]

, 2009
The basic unit of chromatin is the nucleosome; 147 bp of DNA wrapped around an octamer core of histone proteins. Post-translational modifications of these histone proteins have the potential to dramatically alter chromatin structure and dynamics, which ...
Ferdinand, Michelle
core