Results 71 to 80 of about 196,399 (287)

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources

Targets of histone H3 lysine 9 methyltransferases

Frontiers in Cell and Developmental Biology, 2022
Histone H3 lysine 9 di- and trimethylation are well-established marks of constitutively silenced heterochromatin domains found at repetitive DNA elements including pericentromeres, telomeres, and transposons. Loss of heterochromatin at these sites causes genomic instability in the form of aberrant DNA repair, chromosome segregation defects, replication
Aidan J. Levinsky, Aidan J. Levinsky, Gregor McEdwards, Gregor McEdwards, Nasha Sethna, Nasha Sethna, Mark A. Currie, Mark A. Currie   +7 more
openaire   +3 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications

BMC Plant Biology, 2009
Background Histone modifications and histone variants are of importance in many biological processes. To understand the biological functions of the global dynamics of histone modifications and histone variants in higher plants, we elucidated the variants
Lam Hon-Ming, Sun Sai-Ming, Wang Chunmei, Tsai Sau-Na, Yuan Tiezheng, Wu Tao, Ngai Sai-Ming   +6 more
doaj   +1 more source

Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr. [PDF]

, 2013
The molting hormone ecdysone triggers chromatin changes via histone modifications that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-related
Carbonell, Albert, Corominas, Montserrat, Mazo, Alexander, Serras, Florenci   +3 more
core   +2 more sources

Histone H3 lysine 4 methylation revisited [PDF]

Transcription, 2012
Since its discovery more than a decade ago, H3K4 methylation has become synonymous with transcription. We only now have begun to realize that the distinct states of H3K4 methylation have unique distributions and specialized roles in other chromatin-related processes. Here, I discuss recent findings addressing their regulation and functions.
openaire   +2 more sources

The Primary Structure of Yeast Histone H3 [PDF]

European Journal of Biochemistry, 1982
The complete amino acid sequence of histone H3 from Saccharomyces cereviriae (var.) has been established. The protein molecule consists of 135 residues. Since mammalians and yeast diverged from a common ancestor 15 amino acid substitutions have occurred. These substitutions mainly occur in the C-terminal third of the polypeptide chain. The evolutionary
W F, Brandt, C, von Holt
openaire   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly

Cell Reports, 2016
Summary: DNA replication-coupled (RC) nucleosome assembly is mediated by histone chaperones and is fundamental for epigenetic inheritance and maintenance of genomic integrity. The mechanisms that promote this process are only partially understood.
Jiayi Yang, Xu Zhang, Jianxun Feng, He Leng, Shuqi Li, Junyu Xiao, Shaofeng Liu, Zhiyun Xu, Jiawei Xu, Di Li, Zhongshi Wang, Jingyang Wang, Qing Li   +12 more
doaj   +1 more source

The intrinsically disordered distal face of nucleoplasmin recognizes distinct oligomerization states of histones [PDF]

, 2013
The role of Nucleoplasmin (NP) as a H2A-H2B histone chaperone has been extensively characterized. To understand its putative interaction with other histone ligands, we have characterized its ability to bind H3-H4 and histone octamers.
Aloria, K, Arizmendi, JM, Arranz, R, Ausió, J, Fernández-Rivero, N, Finn, R, Muga, A, Prado, A, Ramos, I, Valpuesta, JM   +9 more
core   +1 more source