Results 81 to 90 of about 181,554 (237)

Genome-wide multi-parametric analysis of H2AX or γH2AX distributions during ionizing radiation-induced DNA damage response [PDF]

, 2013
Background: After induction of DNA double strand breaks (DSBs), the DNA damage response (DDR) is activated. One of the earliest events in DDR is the phosphorylation of serine 139 on the histone variant H2AX (gH2AX) catalyzed by phosphatidylinositol 3 ...
Cardoso, Maria Cristina, Durante, Marco, Natale, Francesco, Rapp, Alexander, Taucher-Scholz, Gisela, Yu, Wei   +5 more
core   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]

, 2015
Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei, Gao, Lei, Kim, Yun Ju, Li, Shaofang, Li, Shengben, Liu, Lin, Zhao, Yuanyuan   +6 more
core   +2 more sources

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

The Inheritance of Histone Modifications Depends upon the Location in the Chromosome in Saccharomyces cerevisiae [PDF]

, 2011
Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
A Groth, A Kimura, AL Goldstein, AP Wolffe, AT Annunziato, BJ Thomas, DK Pokholok, F Xu, H Haruki, H Masumoto, H Santos-Rosa, H Santos-Rosa, H Tagami, HB Lindroos, HH Ng, Hiroshi Masumoto, I Celic, J Nakayama, JM Sogo, K Nishimura, K Sugasawa, Katsuhiko Shirahige, KF Verzijlbergen, LN Rusche, LN Rusche, M Lachner, M Radman-Livaja, M Xu, M Yamashita, Masato Kanemaki, Mayumi Hachinohe, MS Longtine, NL Maas, P Cheung, RD Gietz, Ryuichiro Nakato, S Henikoff, S Strahl-Bolsinger, T Kouzarides, T Tanaka, V Jackson, W Fischle, Y Katan-Khaykovich, Yamini Dalal   +43 more
core   +2 more sources

MTFR2‐Mediated Fission Drives Fatty Acid and Mitochondrial Co‐Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis

Advanced Science, EarlyView.
In the tumor margin of hepatocellular carcinoma (HCC), activated hepatic stellate cells upregulate MTFR2, initiating inhibiting DRP1 degradation and mitochondrial fission. This enhances mitochondrial availability and facilitates FAs synthesis via ACC1. Additionally, fission promotes RAC1‐mediated cytoskeletal remodeling and Miro1‐mediated mitochondrial
La Zhang, Baoyong Zhou, Jun Yang, Cong Ren, Jing Luo, Zhenghang Li, Qiang Liu, Zuotian Huang, Zhongjun Wu, Ning Jiang   +9 more
wiley   +1 more source

Acetylation of Histone H3 Lysine 56 Regulates Replication-Coupled Nucleosome Assembly [PDF]

, 2008
SummaryChromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes.
Davies, Brian, Horazdovsky, Bruce, Li, Qing, Verreault, Alain, Wurtele, Hugo, Zhang, Zhiguo, Zhou, Hui   +6 more
core   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients [PDF]

, 2017
Aim: To determine the presence of citrullinated histones in inflamed periodontal tissue and to determine the presence of anti-citrullinated histone autoantibodies in sera from patients with rheumatoid arthritis (RA) and periodontitis (PD) patients ...
Arnett, Brinkmann, Chirivi, Cooper, Corsiero, Dwivedi, Dwivedi, Foulquier, Janssen, Khandpur, Li, Makrygiannakis, McGraw, Neeli, Nesse, Nielen, Pratesi, Rosenstein, Shechter, Smit, Sohn, Stadt, Velden, Vitkov, Wegner, Wegner, White, Willemze, Wright   +28 more
core   +1 more source