Results 81 to 90 of about 196,399 (287)
Dynamic Histone H3 Incorporation Fuels Metastatic Progression [PDF]
Trends in Molecular Medicine, 2019 Treating metastatic cancers is an ongoing challenge in oncology. A recent paper by Gomes and colleagues proposes histone H3 variant dynamics as major regulator of cell fate transition during metastasis and suggests histone chaperones as therapeutic targets for invasive carcinoma.
Simeonova, Iva, Almouzni, Geneviève
openaire +3 more sources
Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs
Advanced Healthcare Materials, EarlyView.Curvature and spatial confinement guide cell behavior in volumetrically printed 3D constructs. Endothelial cells align and spread along specific geometries, while metastatic osteosarcoma cells proliferate independently of structural cues. Label‐free holographic microscopy captures real‐time, long‐term cell–material interactions, highlighting Gel‐PEG's ...
Julia Simińska‐Stanny +3 more
wiley +1 more source
Вавиловский журнал генетики и селекции, 2016 Epigenetic modifications are studied intensively to understand mechanisms of long-term memory. We have shown that histone H3 methylation is important for the defense reflexes formation in the mollusk Helix lucorum.
L. N. Grinkevich, O. V. Vorobiova
doaj +1 more source
A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast. [PDF]
PLoS Genetics, 2012 Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency.
Marta Radman-Livaja +10 more
doaj +1 more source
Histone H3 Cleavage in Severe COVID-19 ICU Patients
Frontiers in Cellular and Infection Microbiology, 2021 The severity of coronavirus disease 19 (COVID-19) is associated with neutrophil extracellular trap (NET) formation. During NET formation, cytotoxic extracellular histones are released, the presence of which is linked to the initiation and progression of ...
Joram Huckriede +10 more
doaj +1 more source
Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning [PDF]
, 2008 Peer reviewedPublisher ...
Botsios, Sotirios +2 more
core +3 more sources
Chromosomal Protein HMGN1 Modulates Histone H3 Phosphorylation [PDF]
Molecular Cell, 2004 Here we demonstrate that HMGN1, a nuclear protein that binds to nucleosomes and reduces the compaction of the chromatin fiber, modulates histone posttranslational modifications. In Hmgn1-/- cells, loss of HMGN1 elevates the steady-state levels of phospho-S10-H3 and enhances the rate of stress-induced phosphorylation of S10-H3.
Lim, Jae-Hwan +6 more
openaire +2 more sources
Advanced Science, EarlyView.In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong +11 more
wiley +1 more source
How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae.
PLoS Genetics, 2011 Global genome nucleotide excision repair removes DNA damage from transcriptionally silent regions of the genome. Relatively little is known about the molecular events that initiate and regulate this process in the context of chromatin.
Shirong Yu +3 more
doaj +1 more source
Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line. [PDF]
PLoS ONE, 2010 Male fertility is declining and an underlying cause may be due to environment-epigenetic interactions in developing sperm, yet nothing is known of how the epigenome controls gene expression in sperm development.
Maren Godmann, Erin May, Sarah Kimmins
doaj +1 more source