Results 241 to 250 of about 287,931 (282)

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Dynamic histone modification signatures coordinate developmental programs in strawberry fruit ripening. [PDF]

Hortic Res
Pan Q, Guo S, Ding J, Zhou Y, Huang X, Qi Q, Wang F, Wu H, Li Y, Gu T.   +9 more
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury. [PDF]

Front Immunol
Guo Y, Ohki S, Kawano Y, Kong WS, Ohno Y, Honda H, Kanno M, Yasuda T.   +7 more
europepmc   +1 more source

A-Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer. [PDF]

Cancers (Basel)
Mohan N, Dashwood RH, Rajendran P.
europepmc   +1 more source

Histone modification-linked prognostic model for ovarian cancer reveals LBX2 as a novel growth promoter. [PDF]

J Cell Mol Med
Xiong J, Liang H, Sun X, Gao K.
europepmc   +1 more source

Integrated analysis of histone modification features in clear cell renal cancer for risk stratification and therapeutic prediction. [PDF]

Transl Oncol
Ma W, Ge Q, Guan Y, Zhang L, Huang L, Chen L, Xu W, Meng J, Yang G, Liang C.   +9 more
europepmc   +1 more source

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Histones and Their Modification

Critical Reviews in Biochemistry, 1986
Histones constitute the protein core around which DNA is coiled to form the basic structural unit of the chromosome known as the nucleosome. Because of the large amount of new histone needed during chromosome replication, the synthesis of histone and DNA is regulated in a complex manner.
R S, Wu, H T, Panusz, C L, Hatch, W M, Bonner   +3 more
openaire   +2 more sources

Histone Variants and Histone Modifications in Neurogenesis

Trends in Cell Biology, 2020
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang, Jinyue Zhao, Yuqing Lv, Wenwen Wang, Chao Feng, Wenzheng Zou, Libo Su, Jianwei Jiao   +7 more
openaire   +2 more sources