Results 111 to 120 of about 2,005,250 (367)
Horizontally Transferred DNA in the Genome of the Fungus Pyricularia oryzae is Associated With Repressive Histone Modifications [PDF]
, 2023 Natsuki Kobayashi +9 more
openalex +1 more source
Cell-specific histone modifications in atherosclerosis
Molecular Medicine Reports, 2018 Histone modifications are the key epigenetic mechanisms that have been identified to regulate gene expression in many human diseases. However, in the early developmental stages, such as in utero and the postnatal stages, histone modifications are ...
Wanlin Jiang +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Epigenetic modifications of histones in cancer
Genome Biology, 2019 The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers.
Zibo Zhao, Ali Shilatifard
doaj +1 more source
TREEOME: A framework for epigenetic and transcriptomic data integration to explore regulatory interactions controlling transcription [PDF]
, 2015 Motivation: Predictive modelling of gene expression is a powerful framework for the in silico exploration of transcriptional regulatory interactions through the integration of high-throughput -omics data.
Budden, David M +2 more
core +2 more sources
The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model*
Molecular & Cellular Proteomics, 2017 Type 2 diabetes (T2D) is a major chronic healthcare concern worldwide. Emerging evidence suggests that a histone-modification-mediated epigenetic mechanism underlies T2D.
Litong Nie +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Rice, 2019 Background Histone modifications play important roles in growth and development of rice (Oryza sativa L.). Lysine butyrylation (Kbu) with a four-carbon chain is a newly-discovered histone acylation modification in rice.
Shuai Liu +9 more
doaj +1 more source
Hyperosmotic priming of arabidopsis seedlings establishes a long-term somatic memory accompanied by specific changes of the epigenome [PDF]
, 2013 <p>Background: In arid and semi-arid environments, drought and soil salinity usually occur at the beginning and end of a plant's life cycle, offering a natural opportunity for the priming of young plants to enhance stress tolerance in mature plants.
Amtmann, A. +4 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source