Results 111 to 120 of about 1,862,085 (289)

Supplementary Figures 1-8, Methods from DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Histone Modifications in Colon Cancer

, 2023
Bilian Jin, Bing Yao, Jian‐Liang Li, C. Robert Fields, Amber L. Delmas, Chen Liu, Keith D. Robertson   +6 more
openalex   +1 more source

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

Advanced Healthcare Materials, EarlyView.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha‐Duong   +4 more
wiley   +1 more source

Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs

Advanced Healthcare Materials, EarlyView.
Curvature and spatial confinement guide cell behavior in volumetrically printed 3D constructs. Endothelial cells align and spread along specific geometries, while metastatic osteosarcoma cells proliferate independently of structural cues. Label‐free holographic microscopy captures real‐time, long‐term cell–material interactions, highlighting Gel‐PEG's ...
Julia Simińska‐Stanny, Pierre Tournier, Armin Shavandi, Shukry J Habib   +3 more
wiley   +1 more source

The BAF complex enhances transcription through interaction with H3K56ac in the histone globular domain

Nature Communications
Histone post-translational modifications play pivotal roles in eukaryotic gene expression. To date, most studies have focused on modifications in unstructured histone N-terminal tail domains and their binding proteins. However, transcriptional regulation
Kwangbeom Hyun, Jihye Ahn, Hyoungmin Kim, Jihyun Kim, Yong-In Kim, Hee-Sung Park, Robert G. Roeder, J. Eugene Lee, Jaehoon Kim   +8 more
doaj   +1 more source

Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets [PDF]

, 2023
Ruiqi Liu, Jiajun Wu, H. Henry Guo, Weiping Yao, Shuang Li, Yanwei Lu, Yongshi Jia, Xiaodong Liang, Jianming Tang, Haibo Zhang   +9 more
openalex   +1 more source

Chemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues

Advanced Materials, EarlyView.
Understanding the bi‐directional crosstalk between cells and their surrounding extracellular matrix (ECM) is critical for tissue engineering. This study presents a chemoselective strategy for proteomic profiling of newly deposited ECM from resident cells.
Zihan Ling, Burke Niego, Qingyang Li, Dhruv Bhattaram, Vanessa Serna Villa, Michael Hu, Zhuowei Gong, Lloyd M. Smith, Brian L. Frey, Xi Ren   +9 more
wiley   +1 more source

Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice

Scientific Reports
During the development of multicellular organisms and cell differentiation, the chromatin structure in the cell nucleus undergoes extensive changes, and the nucleosome structure is formed by a combination of various histone variants.
Takayuki Kawaguchi, Michihiro Hashimoto, Reiko Nakagawa, Ryunosuke Minami, Masahito Ikawa, Jun-ichi Nakayama, Jun Ueda   +6 more
doaj   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Regulation of chromatin by histone modifications

Cell Research, 2011
Andrew J. Bannister, T. Kouzarides
semanticscholar   +1 more source