Results 141 to 150 of about 2,005,250 (367)

Aberrant histone modification in endometriosis

Frontiers in Bioscience, 2014
Accumulating evidence suggests that epigenetic aberrations play definite roles in the pathogenesis of endometriosis. These include aberrations in genomic DNA methylation, microRNA expression, and histone modification. The aberrant histone modification status and the aberrant expression of histone deacetylases, which regulate histone acetylation, in ...
Kaei, Nasu, Yukie, Kawano, Kentaro, Kai, Yoko, Aoyagi, Wakana, Abe, Mamiko, Okamoto, Hisashi, Narahara   +6 more
openaire   +2 more sources

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

Nature Communications, 2016
Centromeres consist of specialized centrochromatin containing CENP-A nucleosomes intermingled with H3 nucleosomes carrying transcription-associated modifications.
Oscar Molina, Giulia Vargiu, M. A. Abad, Alisa Zhiteneva, A. Jeyaprakash, H. Masumoto, N. Kouprina, V. Larionov, W. Earnshaw   +8 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Chromatin comprises the approximately 3 billion bases in the human genome and histone proteins. Histone posttranslational modifications (PTMs) regulate chromatin dynamics and protein transcription to expand the genetic code.
J. Galligan, James A. Wepy, Matthew D. Streeter, P. Kingsley, M. M. Mitchener, Orrette R Wauchope, William N. Beavers, Kristie L. Rose, Tina Wang, D. Spiegel, L. Marnett   +10 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The Expanding Constellation of Histone Post-Translational Modifications in the Epigenetic Landscape [PDF]

, 2021
Vincenzo Cavalieri
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Histone modifications induced by ethanol are modulated by genotype, brain region studied, and timing of ethanol exposure

Frontiers in Molecular Neuroscience, 2015
Background: Emerging research implicates ethanol (EtOH)-induced epigenetic modifications in regulating gene expression and EtOH consumption. However, consensus on specific epigenetic modifications induced by EtOH has not yet emerged, making it ...
Andrey eFinegersh, Carolyn eFerguson, Seth eMaxwell, David eMazariegos, Daniel eFarrell, Gregg E Homanics   +5 more
doaj   +1 more source

Characterization of histone acylations links chromatin modifications with metabolism

Nature Communications, 2017
Over the last decade, numerous histone acyl post-translational modifications (acyl-PTMs) have been discovered, of which the functional significance is still under intense study.
Johayra Simithy, Simone Sidoli, Zuo-Fei Yuan, Mariel Coradin, N. Bhanu, Dylan M. Marchione, B. J. Klein, Gleb A. Bazilevsky, C. McCullough, Robert S. Magin, T. Kutateladze, N. Snyder, R. Marmorstein, B. Garcia   +13 more
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source