Results 161 to 170 of about 1,862,085 (289)

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Epigenetic memory: The role of the crosstalk between histone modifications and DNA methylation. [PDF]

Comput Struct Biotechnol J
Del Vecchio D.
europepmc   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

Histone modifications in the regulation of erythropoiesis. [PDF]

Ann Med
Wu X, Xu H, Xia E, Gao L, Hou Y, Sun L, Zhang H, Cheng Y.   +7 more
europepmc   +1 more source

Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus‐specific CD8⁺ T cells [PDF]

, 2015
Michelle Nguyen, Lauren A. Hatton, Jasmine Li, Moshe Olshansky, Anne Kelso, Brendan E. Russ, Stephen T. Turner   +6 more
openalex   +1 more source

Gene Editing of a Susceptibility LncRNA Enhances Broad‐Spectrum Disease Resistance in Rice without Developmental Trade‐Offs

Advanced Science, EarlyView.
Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication‐acquired, pathogen‐induced lncRNA, promotes protein N‐terminal acetylation through its interaction with NatA complex. Knockout of RESIS increases translation and confers broad‐spectrum resistance to both fungal and bacterial ...
Wen‐long Zhao, Ye Cheng, Jia‐hui Huang, Jun‐jie Feng, Hui‐yin Pang, Yi‐chao Qin, Zheng‐tong Chen, Yu Cheng, Jian‐ping Lian, Yan‐fei Zhou, Rui‐rui He, Meng‐qi Lei, Zi‐qin Cao, Lu Yang, Chao Yuan, Jie Jiang, Yue‐qin Chen, Yu‐chan Zhang   +17 more
wiley   +1 more source

Aberrant histone modifications in pediatric brain tumors. [PDF]

Front Oncol
Hamanishi ET, Dang D, Venneti S.
europepmc   +1 more source

Transcription-coupled deposition of histone modifications during MHC class II gene activation [PDF]

, 2007
Natalia Rybtsova, Elisa Leimgruber, Queralt Seguín-Estévez, Isabelle Dunand-Sauthier, Michał Krawczyk, Walter Reith   +5 more
openalex   +1 more source

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Nature, 2009
Nathaniel D. Heintzman, G. Hon, R. D. Hawkins, Pouya Kheradpour, A. Stark, L. F. Harp, Z. Ye, Leonard K. Lee, R. Stuart, Christina W. Ching, K. Ching, Jessica Antosiewicz-Bourget, Hui Liu, Xinmin Zhang, Roland Green, Victor V Lobanenkov, R. Stewart, J. Thomson, G. Crawford, Manolis Kellis, B. Ren   +20 more
semanticscholar   +1 more source

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source