Results 171 to 180 of about 1,862,085 (289)

TET1 loss propels the development of hyperthyroidism by remodeling histone modifications of PAX8 promoter. [PDF]

Exp Mol Med
Dang H, Liu Y, Zhou Y, Sui M, Wang Y, Qiang W, Sui F, Zhang Y, Cao H, Wu X, Ji M, Hou P.   +11 more
europepmc   +1 more source

Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer [PDF]

, 2011
Maria S. Iliou, Amaia Lujambio, Anna Portela, Oliver Brüstle, Philipp Koch, Per Henrik Andersson-Vincent, Erik Sundström, Outi Hovatta, Manel Esteller   +8 more
openalex   +1 more source

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source

Hypoxia-Driven Histone Modifications Govern Gene Regulation for Mature Eye Lens Formation. [PDF]

Invest Ophthalmol Vis Sci
Brennan L, Disatham J, Kantorow M.
europepmc   +1 more source

Lateral Thinking: How Histone Modifications Regulate Gene Expression.

Trends in Genetics, 2016
Moyra Lawrence, S. Daujat, R. Schneider
semanticscholar   +1 more source

Super‐Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

Advanced Science, EarlyView.
A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba, Miroslav Kuba, Tomáš Kraus, Kerem Celikay, Janis Meyer, Sunil Kumar Pradhan, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Karl Rohr, Michal Hocek, M. Cristina Cardoso   +11 more
wiley   +1 more source

Characterization of histone modifications inside nucleosome H4K31ac and H4K31me1 in Apicomplexan parasites

, 2017
Fabien Sindikubwabo
openalex   +1 more source

Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma

Yang Xiao, Yikai Zhang, Yuyang Hu, Xupeng Zhang, Jiaqi Tan, Shanhu Yao, Xingwei Wang, Yuexiang Qin   +7 more
openalex   +1 more source

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Advanced Science, EarlyView.
This study identifies that RBM10 represses the transcriptional activity of RORB in liquid condensates, resulting in down‐regulation of NR1D1 and RIOK3 that further activates NF‐κB activity to facilitate lysosomal biogenesis and aggressive features of NB cells.
Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong   +9 more
wiley   +1 more source

Role of vascular smooth muscle phenotypic transformation induced by histone modifications in the development of abdominal aortic aneurysms. [PDF]

Clin Epigenetics
Chen Z, Sun Y, Zhu P, Zhang L, Yang J, Zhang J.   +5 more
europepmc   +1 more source