Advanced Science, EarlyView.This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo +40 more
wiley +1 more source
Temporal and Spatial Changes in Transcription Factor Binding and Histone Modifications at the Steroidogenic Acute Regulatory Protein (StAR) Locus Associated withStARTranscription [PDF]
, 2004 Hisahiko Hiroi +5 more
openalex +1 more source
Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression
Advanced Science, EarlyView.Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo +15 more
wiley +1 more source
Tissue-Specific Expression and Post-Translational Modification of Histone H3 Variants
, 2008 Benjamin A. García +3 more
openalex +1 more source
Advanced Science, EarlyView.The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan +9 more
wiley +1 more source
Proteome-wide identification of lysine 2-hydroxyisobutyrylation reveals conserved and novel histone modifications in Physcomitrella patens [PDF]
, 2017 Zhiming Yu +4 more
openalex +1 more source
A histone modification-based synthetic circuit to engineer temporal gene expression in Arabidopsis floral meristems [PDF]
, 2022 Margaret Anne Pelayo +7 more
openalex +1 more source
Advanced Science, EarlyView.This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche +21 more
wiley +1 more source
Epigenome Modifying Tools In Asthma [PDF]
, 2015 Adcock,, Brook, PO, Durham, AL, Perry, M
core +1 more source
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Nature, 2009 Nathaniel D. Heintzman +20 more
semanticscholar +1 more source