Results 291 to 300 of about 2,005,250 (367)

How histone modifications influence cellular radiosensitivity: Pharmaceutically targeting epigenetic regulators as a promising avenue to overcome radioresistance. [PDF]

Acta Pharm Sin B
Song J, Ye L, Ding WQ, Qiao H, Dai J, Bai H, Zhang S.   +6 more
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications. [PDF]

Front Oncol
Sharma B, Shekhar H, Sahu A, Kaur D, Haque S, Tuli HS, Sharma H, Sharma U.   +7 more
europepmc   +1 more source

Melatonin and spermidine protect early mouse embryos from ethylparaben toxicity by restoring histone modifications and subcellular structures

Yongfeng Wang, Yibo Wan, Qing Tian, Ying Yin, Jiawei Xu, Liquan Zhou   +5 more
openalex   +1 more source

Additional file 9: of Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos

, 2019
Wei Zhu, Xiaocui Xu, Xinxin Wang, Jiang Liu   +3 more
openalex   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

The Functions and Regulatory Mechanisms of Histone Modifications in Skeletal Muscle Development and Disease. [PDF]

Int J Mol Sci
Huang Z, Hu L, Liu Z, Wang S.
europepmc   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Deciphering the role of histone modifications in memory and exhausted CD8 T cells. [PDF]

Sci Rep
Huang H, Baxter AE, Zhang Z, Good CR, Alexander KA, Chen Z, Garcia PAA, Samareh P, Collins SM, Glastad KM, Wang L, Donahue G, Manne S, Giles JR, Shi J, Berger SL, Wherry EJ.   +16 more
europepmc   +1 more source

Impact de l'acclimatation embryonnaire à la chaleur sur des modifications post-traductionnelles des histones chez le poulet

, 2017
Sarah-Anne David
openalex   +1 more source