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Functional consequences of histone modifications
Current Opinion in Genetics & Development, 2003Covalent modifications of the histone proteins have well-known roles in gene expression. Experiments reported during the past year have extended this paradigm to include roles for histone acetylation and phosphorylation in DNA double-strand break repair.
Masayoshi, Iizuka, M Mitchell, Smith
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Histone Modification Therapy of Cancer
2010The state of modification of histone tails plays an important role in defining the accessibility of DNA for the transcription machinery and other regulatory factors. It has been extensively demonstrated that the posttranslational modifications of the histone tails, as well as modifications within the nucleosome domain, regulate the level of chromatin ...
Chiara, Biancotto +2 more
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2013
Histone posttranslational modifications (PTM) constitute one of the most important signaling pathways in the eukaryotic nucleus. In this chapter, we will discuss the molecular mechanisms by which histone PTM are deciphered by chromatin regulators and the functional outcomes of reading this signaling system.
Chun Ruan, Bing Li
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Histone posttranslational modifications (PTM) constitute one of the most important signaling pathways in the eukaryotic nucleus. In this chapter, we will discuss the molecular mechanisms by which histone PTM are deciphered by chromatin regulators and the functional outcomes of reading this signaling system.
Chun Ruan, Bing Li
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Global patterns of histone modifications
Current Opinion in Genetics & Development, 2007Histones, the proteins that package eukaryotic genomes into chromatin, are subject to a huge number and variety of covalent modifications. In the past few years, genomic technologies such as microarray hybridization have been applied to the study of histone modifications. These studies shed significant light on the role of covalent modifications in DNA-
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The language of covalent histone modifications
Nature, 2000B. Strahl, C. Allis
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Histone Modifications in Corepressor Functions
2004Publisher Summary This chapter emphasizes histone modifications in corepressor functions. Histone modifications play a regulatory role in gene expression by altering higher order chromatin structures and by providing docking sites for non-histone regulatory proteins. Many corepressor complexes contain or recruit histone-modifying activities.
Judith K, Davie, Sharon Y R, Dent
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