Results 81 to 90 of about 1,862,085 (289)

Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man

EMBO Reports, 2016
It is striking that within a eukaryotic nucleus, the genome can assume specific spatiotemporal distributions that correlate with the cell's functional states. Cell identity itself is determined by distinct sets of genes that are expressed at a given time.
Jennifer C. Harr, Adriana Gonzalez‐Sandoval, S. Gasser   +2 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model*

Molecular & Cellular Proteomics, 2017
Type 2 diabetes (T2D) is a major chronic healthcare concern worldwide. Emerging evidence suggests that a histone-modification-mediated epigenetic mechanism underlies T2D.
Litong Nie, Lin Shuai, Mingrui Zhu, Ping Liu, Zhifu Xie, Shangwen Jiang, Haowen Jiang, Jia Li, Yingming Zhao, Jing-Ya Li, Minjia Tan   +10 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Protein kinase C coordinates histone H3 phosphorylation and acetylation

eLife, 2015
The re-assembly of chromatin following DNA replication is a critical event in the maintenance of genome integrity. Histone H3 acetylation at K56 and phosphorylation at T45 are two important chromatin modifications that accompany chromatin assembly.
Zoulfia Darieva, Aaron Webber, Stacey Warwood, Andrew D Sharrocks   +3 more
doaj   +1 more source

Effects of acute heat stress on protein expression and histone modification in the adrenal gland of male layer-type country chickens [PDF]

, 2021
Hao-Teng Zheng, Zi-Xuan Zhuang, Chao‐Jung Chen, Hsin-Yi Liao, Hung-Lin Chen, Huang-Chun Hsueh, Chih‐Feng Chen, Shuen‐Ei Chen, San‐Yuan Huang   +8 more
openalex   +1 more source

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

Nature Communications, 2016
Centromeres consist of specialized centrochromatin containing CENP-A nucleosomes intermingled with H3 nucleosomes carrying transcription-associated modifications.
Oscar Molina, Giulia Vargiu, M. A. Abad, Alisa Zhiteneva, A. Jeyaprakash, H. Masumoto, N. Kouprina, V. Larionov, W. Earnshaw   +8 more
semanticscholar   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Histone Modifications and the Maintenance of Telomere Integrity

Cells, 2019
Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play an integral role in protecting linear DNA from degradation. Dysregulation of telomeres can result in genomic instability and has been implicated in increased rates of ...
Meagan Jezek, Erin M. Green
doaj   +1 more source