Results 81 to 90 of about 2,005,250 (367)

Dynamic Histone H3 Modifications Regulate Meiosis Initiation via Respiration

Frontiers in Cell and Developmental Biology, 2021
Meiosis is essential for genetic stability and diversity during sexual reproduction in most eukaryotes. Chromatin structure and gene expression are drastically changed during meiosis, and various histone modifications have been reported to participate in
Jian Shi, Yanjie Ma, Hui Hua, Yujiao Liu, Wei Li, Hongxiu Yu, Chao Liu   +6 more
doaj   +1 more source

Abnormal Neural Differentiation in Response to Graphene Quantum Dots through Histone Modification Interference [PDF]

, 2022
Tingting Ku, Zhihua Ren, Renjun Yang, Qian S. Liu, Nan Sang, Francesco Faiola, Qunfang Zhou, Guibin Jiang   +7 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Displacement of Histones at Promoters of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation [PDF]

, 2006
Chromatin remodeling at promoters of activated genes spans from mild histone modifications to outright displacement of nucleosomes in trans. Factors affecting these events are not always clear.
Erkina, Tamara Y., Erkine, Alexander M.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Supplementary Figure 1 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development [PDF]

, 2023
Tina Bianco‐Miotto, Karen Chiam, Grant Buchanan, Shalini Jindal, Tanya K. Day, Mervyn G. Thomas, Marie Pickering, Melissa A. O'Loughlin, Natalie K. Ryan, Wendy A. Raymond, Lisa G. Horvath, James G. Kench, Phillip D. Stricker, Villis R. Marshall, Robert L. Sutherland, Susan M. Henshall, William L. Gerald, Howard I. Scher, Gail P. Risbridger, Judith A. Clements, Lisa M. Butler, Wayne D. Tilley, David J. Horsfall, Carmela Ricciardelli   +23 more
openalex   +1 more source

Different Behavioral Experiences Produce Distinctive Parallel Changes in, and Correlate With, Frontal Cortex and Hippocampal Global Post-translational Histone Levels. [PDF]

, 2018
While it is clear that behavioral experience modulates epigenetic profiles, it is less evident how the nature of that experience influences outcomes and whether epigenetic/genetic biomarkers could be extracted to classify different types of behavioral ...
Cory-Slechta, Deborah A., Schneider, Jay S., Singh, Garima, Sobolewski, Marissa   +3 more
core   +2 more sources

DeepHistone: a deep learning approach to predicting histone modifications

BMC Genomics, 2018
Quantitative detection of histone modifications has emerged in the recent years as a major means for understanding such biological processes as chromosome packaging, transcriptional activation, and DNA damage.
Qijin Yin, Mengmeng Wu, Qiao Liu, Hairong Lv, R. Jiang   +4 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Distinctive core histone post-translational modification patterns in Arabidopsis thaliana. [PDF]

PLoS ONE, 2007
Post-translational modifications of histones play crucial roles in the genetic and epigenetic regulation of gene expression from chromatin. Studies in mammals and yeast have found conserved modifications at some residues of histones as well as non ...
Kangling Zhang, Vaniyambadi V Sridhar, Jianhua Zhu, Avnish Kapoor, Jian-Kang Zhu   +4 more
doaj   +1 more source