Histone variants at a glance. [PDF]
J Cell Sci, 2021 Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA entering and exiting the particle may be bound by the linker histone H1.
Talbert PB, Henikoff S.
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The Role of MacroH2A Histone Variants in Cancer. [PDF]
Cancers (Basel), 2021 Simple Summary The structural unit of chromatin is the nucleosome that is composed of DNA wrapped around a core of eight histone proteins. Histone variants can replace ‘standard’ histones at specific sites of the genome.
Hsu CJ, Meers O, Buschbeck M, Heidel FH.
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Short H2A histone variants are expressed in cancer. [PDF]
Nat Commun, 2021 Short H2A (sH2A) histone variants are primarily expressed in the testes of placental mammals. Their incorporation into chromatin is associated with nucleosome destabilization and modulation of alternate splicing. Here, we show that sH2As innately possess
Chew GL +6 more
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LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2. [PDF]
Nucleic Acids Res, 2021 LSH, a homologue of the ISWI/SNF2 family of chromatin remodelers, is required in vivo for deposition of the histone variants macroH2A1 and macroH2A2 at specific genomic locations.
Ni K, Muegge K.
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Histone variants and chromatin structure, update of advances [PDF]
Computational and Structural Biotechnology Journal, 2023 Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility.
Vladyslava Sokolova +2 more
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HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs. [PDF]
Nucleic Acids Res, 2022 Histone variants have been implicated in regulating chromatin dynamics and genome functions. Previously, we have shown that histone variant H3.3 actively marks enhancers and cooperates with H2A.Z at promoters to prime the genes into a poised state in ...
Yang Y +11 more
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Histone variants: key regulators of inflammation in cell dedifferentiation and transdifferentiation [PDF]
Frontiers in ImmunologyHistone variants are specialized isoforms of histone proteins that play crucial roles in regulating chromatin structure and function, influencing transcription, DNA repair, and cell cycle progression.
Manlio Vinciguerra, Desislava K. Tsoneva
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Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2. [PDF]
EMBO J, 2021 Nucleosomes are dynamic entities with wide‐ranging compositional variations. Human histone variants H2A.B and H2A.Z.2.2 play critical roles in multiple biological processes by forming unstable nucleosomes and open chromatin structures, but how H2A.B and ...
Zhou M +8 more
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Histone variants in archaea and the evolution of combinatorial chromatin complexity. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Chromatin in eukaryotes is built around histone–DNA complexes, which act as platforms for the integration of regulatory information. Different layers of information are integrated in a combinatorial fashion, for example by exchanging core ...
Stevens KM +6 more
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Elucidating the influence of linker histone variants on chromatosome dynamics and energetics. [PDF]
Nucleic Acids Res, 2020 Linker histones are epigenetic regulators that bind to nucleosomes and alter chromatin structures and dynamics. Biophysical studies have revealed two binding modes in the linker histone/nucleosome complex, the chromatosome, where the linker histone is ...
Woods DC, Wereszczynski J.
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