Results 21 to 30 of about 1,411,447 (295)
Plant Histone HTB (H2B) Variants in Regulating Chromatin Structure and Function
Plants, 2020 Besides chemical modification of histone proteins, chromatin dynamics can be modulated by histone variants. Most organisms possess multiple genes encoding for core histone proteins, which are highly similar in amino acid sequence.
Janardan Khadka +2 more
doaj +2 more sources
Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Nucleosomes are the base units that organize eukaryotic genomes. Besides the canonical histone, histone variants create unique local chromatin domains that fine-tune transcription, replication, DNA damage repair, and faithful chromosome ...
Melters DP +6 more
europepmc +2 more sources
Short Histone H2A Variants: Small in Stature but not in Function
Cells, 2020 The dynamic packaging of DNA into chromatin regulates all aspects of genome function by altering the accessibility of DNA and by providing docking pads to proteins that copy, repair and express the genome.
Xuanzhao Jiang +2 more
doaj +2 more sources
The roles of histone variants in fine-tuning chromatin organization and function. [PDF]
Nat Rev Mol Cell Biol, 2020 Martire S, Banaszynski LA.
europepmc +2 more sources
DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression [PDF]
Cell Reports, 2019 Summary: The DUX4 transcription factor is briefly expressed in the early cleavage-stage embryo, where it induces an early wave of zygotic gene transcription, whereas its mis-expression in skeletal muscle causes the muscular dystrophy facioscapulohumeral ...
Rebecca Resnick +8 more
doaj +2 more sources
Visualizing the dynamics of histone variants in the S-phase nucleus [PDF]
Genome Biology, 2018 Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized.
Stella Maxouri +2 more
doaj +2 more sources
Casting histone variants during mammalian reproduction. [PDF]
Chromosoma, 2023 AbstractDuring mammalian reproduction, germ cell chromatin packaging is key to prepare parental genomes for fertilization and to initiate embryonic development. While chromatin modifications such as DNA methylation and histone post-translational modifications are well known to carry regulatory information, histone variants have received less attention ...
Karam G, Molaro A.
europepmc +3 more sources
Histone variants and epigenetics. [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin ...
S. Henikoff, M. Mitchell Smith
semanticscholar +3 more sources
Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Cells, 2020 The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law +2 more
doaj +1 more source
Journal of Integrative Neuroscience, 2023 Neurodevelopment is a highly regulated process that relies on the precise regulation of gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the proper execution of developmental gene expression programs.
Karanveer S Johal +2 more
doaj +1 more source