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Histones: The critical players in innate immunity
The highly conserved histones in different species seem to represent a very ancient and universal innate host defense system against microorganisms in the biological world. Histones are the essential part of nuclear matter and act as a control switch for
Xia Li+6 more
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Structure and function of archaeal histones. [PDF]
The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes.
Bram Henneman+3 more
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Bactericidal activity of mammalian histones is caused by large membrane pore formation [PDF]
Summary: Histones have an important role in eukaryotic innate immunity, wherein histones co-localize with antimicrobial peptides (AMPs). The mechanism of histone cooperation with AMPs and the extent to which histones form pores both remain a mystery ...
Leora Duong+13 more
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Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis [PDF]
Cellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta+5 more
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Rapid purification of recombinant histones. [PDF]
The development of methods to assemble nucleosomes from recombinant histones decades ago has transformed chromatin research. Nevertheless, nucleosome reconstitution remains time consuming to this day, not least because the four individual histones must ...
Henrike Klinker+4 more
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Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress [PDF]
Histones are conserved nuclear proteins that function as part of the nucleosome in the regulation of chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals, and when elevated, may ...
Birendra Singh+12 more
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In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role. [PDF]
Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are released during acute inflammation, and therefore might interact with circulating lipoproteins
Alan D Pemberton, Jeremy K Brown
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Histones have a specific key role in the remodeling of chromatin and gene transcription. In the blood, free histones are damage-connected proteins. Myelin basic protein (MBP) is the major component of the myelin-proteolipid sheath of axons.
Georgy A. Nevinsky+2 more
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N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice. [PDF]
Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind histones through electrostatic interaction. The
Yanlin Zhang+11 more
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Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis and infection - induced cell death, histones are released from the cell.
Asaf Sol+4 more
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