Results 1 to 10 of about 61,334 (223)
Rapid purification of recombinant histones. [PDF]
PLoS ONE, 2014 The development of methods to assemble nucleosomes from recombinant histones decades ago has transformed chromatin research. Nevertheless, nucleosome reconstitution remains time consuming to this day, not least because the four individual histones must ...
Henrike Klinker +4 more
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In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role. [PDF]
PLoS ONE, 2010 Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are released during acute inflammation, and therefore might interact with circulating lipoproteins
Alan D Pemberton, Jeremy K Brown
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Biomedicines, 2022 Histones have a specific key role in the remodeling of chromatin and gene transcription. In the blood, free histones are damage-connected proteins. Myelin basic protein (MBP) is the major component of the myelin-proteolipid sheath of axons.
Georgy A. Nevinsky +2 more
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N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice. [PDF]
PLoS ONE, 2014 Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind histones through electrostatic interaction. The
Yanlin Zhang +11 more
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Structure and function of archaeal histones. [PDF]
PLoS Genetics, 2018 The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes.
Bram Henneman +3 more
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Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM
Frontiers in Molecular Biosciences, 2022 Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin +3 more
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Frontiers in Microbiology, 2016 Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis and infection - induced cell death, histones are released from the cell.
Asaf Sol +4 more
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Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation. [PDF]
PLoS ONE, 2016 The high circulating levels of histones found in various thrombotic diseases may compromise the anticoagulant barrier of endothelial cells. We determined how histones affect endothelial procoagulant tissue factor (TF) and anticoagulant thrombomodulin (TM)
Ji Eun Kim +3 more
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The role of histones in the immune responses of aquatic invertebrates [PDF]
Invertebrate Survival Journal, 2013 Histones are primary components of eukaryotic chromatin and highly abundant in all animal cells. In addition to their important role in chromatin structure and transcriptional regulation, histones contribute to innate immune responses. In several aquatic
C Nikapitiya +2 more
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Abstract P-20: Linker Histone H1: The Interplay between Chromatosome Stability, Oncomutations and Post-Translational Modifications [PDF]
International Journal of Biomedicine, 2019 Background: Variations in the sequence of linker histone (LH) H1 play an important role in the modulation of chromatin functioning. Meanwhile, an effect of LH variations on the chromatin structure remains unclear.
Mikhail V. Bass +2 more
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