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Histones: The critical players in innate immunity

open access: yesFrontiers in Immunology, 2022
The highly conserved histones in different species seem to represent a very ancient and universal innate host defense system against microorganisms in the biological world. Histones are the essential part of nuclear matter and act as a control switch for
Xia Li   +6 more
doaj   +2 more sources

Structure and function of archaeal histones. [PDF]

open access: yesPLoS Genetics, 2018
The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes.
Bram Henneman   +3 more
doaj   +2 more sources

Bactericidal activity of mammalian histones is caused by large membrane pore formation [PDF]

open access: yesCell Reports
Summary: Histones have an important role in eukaryotic innate immunity, wherein histones co-localize with antimicrobial peptides (AMPs). The mechanism of histone cooperation with AMPs and the extent to which histones form pores both remain a mystery ...
Leora Duong   +13 more
doaj   +2 more sources

Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis [PDF]

open access: yesCurrent Issues in Molecular Biology
Cellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta   +5 more
doaj   +2 more sources

Rapid purification of recombinant histones. [PDF]

open access: yesPLoS ONE, 2014
The development of methods to assemble nucleosomes from recombinant histones decades ago has transformed chromatin research. Nevertheless, nucleosome reconstitution remains time consuming to this day, not least because the four individual histones must ...
Henrike Klinker   +4 more
doaj   +2 more sources

Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress [PDF]

open access: yesJournal of Extracellular Vesicles
Histones are conserved nuclear proteins that function as part of the nucleosome in the regulation of chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals, and when elevated, may ...
Birendra Singh   +12 more
doaj   +2 more sources

In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role. [PDF]

open access: yesPLoS ONE, 2010
Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are released during acute inflammation, and therefore might interact with circulating lipoproteins
Alan D Pemberton, Jeremy K Brown
doaj   +1 more source

Multiple Sclerosis: Enzymatic Cross Site-Specific Recognition and Hydrolysis of H3 Histone by IgGs against H3, H1, H2A, H2B, H4 Histones, Myelin Basic Protein, and DNA

open access: yesBiomedicines, 2022
Histones have a specific key role in the remodeling of chromatin and gene transcription. In the blood, free histones are damage-connected proteins. Myelin basic protein (MBP) is the major component of the myelin-proteolipid sheath of axons.
Georgy A. Nevinsky   +2 more
doaj   +1 more source

N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice. [PDF]

open access: yesPLoS ONE, 2014
Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind histones through electrostatic interaction. The
Yanlin Zhang   +11 more
doaj   +1 more source

Actin and DNA protect histones from degradation by bacterial proteases but inhibit their antimicrobial activity

open access: yesFrontiers in Microbiology, 2016
Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis and infection - induced cell death, histones are released from the cell.
Asaf Sol   +4 more
doaj   +1 more source

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