Results 101 to 110 of about 317,398 (334)

Antimicrobial Histones and DNA Traps in Invertebrate Immunity

Journal of Biological Chemistry, 2014
Background: How antimicrobial histones participate in invertebrate defense was still unclear. Results: Upon injury or infection, oyster immune cells release antimicrobial histones and extracellular DNA traps in a ROS-dependent manner.
Aurore C. Poirier, P. Schmitt, Rafael D. Rosa, Audrey S Vanhove, S. Kieffer-Jaquinod, Tristan Rubio, G. Charrière, D. Destoumieux-Garzón   +7 more
semanticscholar   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Inheritance of Histones H3 and H4 during DNA Replication In Vitro

Cell Reports, 2017
Summary: Nucleosomes are believed to carry epigenetic information through the cell cycle, including through DNA replication. It has been known for decades that parental histones are reassembled on newly replicated chromatin, but the mechanisms underlying
Egbert Vincent Madamba, Ellora Bellows Berthet, Nicole Jane Francis   +2 more
doaj  

Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4.

Journal of the American Society of Nephrology, 2012
In AKI, dying renal cells release intracellular molecules that stimulate immune cells to secrete proinflammatory cytokines, which trigger leukocyte recruitment and renal inflammation.
Ramanjaneyulu Allam, C. R. Scherbaum, M. Darisipudi, S. R. Mulay, H. Hägele, J. Lichtnekert, Jan Hagemann, K. V. Rupanagudi, Mi Ryu, Claudia Schwarzenberger, B. Hohenstein, C. Hugo, B. Uhl, C. Reichel, F. Krombach, M. Monestier, H. Liapis, K. Moreth, L. Schaefer, H. Anders   +19 more
semanticscholar   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Histone H1, the Forgotten Histone [PDF]

Epigenomics, 2019
Robert Schneider, Kevin Brockers
openaire   +2 more sources

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones*

Journal of Biological Chemistry, 2013
Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic ...
C. Longstaff, Imre Varjú, P. Sótonyi, L. Szabó, M. Krumrey, A. Hoell, A. Bóta, Z. Varga, E. Komorowicz, K. Kolev   +9 more
semanticscholar   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Histones of Mitosis and Meiosis in Loxa flavicolis (Hemipteran) [PDF]

, 1958
Hudson R. Ansley
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source