Results 11 to 20 of about 239,429 (335)
Histones and histone variant families in prokaryotes
Nature CommunicationsHistones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different ...
Samuel Schwab +8 more
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Bactericidal activity of mammalian histones is caused by large membrane pore formation [PDF]
Cell ReportsSummary: Histones have an important role in eukaryotic innate immunity, wherein histones co-localize with antimicrobial peptides (AMPs). The mechanism of histone cooperation with AMPs and the extent to which histones form pores both remain a mystery ...
Leora Duong +13 more
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Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Marc-André Laniel, Craig L. Peterson
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In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role. [PDF]
PLoS ONE, 2010 Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are released during acute inflammation, and therefore might interact with circulating lipoproteins
Alan D Pemberton, Jeremy K Brown
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Rapid purification of recombinant histones. [PDF]
PLoS ONE, 2014 The development of methods to assemble nucleosomes from recombinant histones decades ago has transformed chromatin research. Nevertheless, nucleosome reconstitution remains time consuming to this day, not least because the four individual histones must ...
Henrike Klinker +4 more
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HISTONES AND DIFFERENTIATION [PDF]
Proceedings of the National Academy of Sciences, 1963 Betty C. Moore
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Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]
, 2020 Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert +58 more
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Modern concepts of the molecular pathogenesis of thyroid cancer
Успехи молекулярной онкологии, 2021 Thyroid cancer remains the most common malignancy of the endocrine system worldwide. The indicators of its morbidity and mortality rates have been increasing rapidly over the last decades.
A. A. Mikhailova +10 more
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Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
Cells, 2022 NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil “explosion” and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins.
Rebeca Osca-Verdegal +8 more
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H2A-H2B Histone Dimer Plasticity and Its Functional Implications
Cells, 2022 The protein core of the nucleosome is composed of an H3-H4 histone tetramer and two H2A-H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers lock the flanking DNA segments. Being positioned at the sides of the nucleosome,
Anastasiia S. Kniazeva +2 more
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