Results 251 to 260 of about 245,589 (335)

Isolevuglandins Modulate Histone H1 in Myeloid Cells in Salt-Sensitive Hypertension. [PDF]

Circ Res
Afolabi JM, Saleem M, Kirabo A, Mutchler AL.   +3 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Lactate and lactylation in macrophage polarization of sepsis. [PDF]

Front Cell Infect Microbiol
Sun J, Zhang M, Zhang L, Zhang X, Zhang J.   +4 more
europepmc   +1 more source

Author Response: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe

Fouad Ouasti, Maxime Audin, Karine Fréon, Jean‐Pierre Quivy, Mehdi Tachekort, Elizabeth Cesard, Aurélien Thureau, Virginie Ropars, Paloma F. Varela, Gwénaëlle Moal, Ibrahim Soumana Amadou, Aleksandra Uryga, Pierre Legrand, Jessica Andréani, Raphaël Guérois, Geneviève Almouzni, Sarah Lambert, Françoise Ochsenbein   +17 more
openalex   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Damage-Associated Molecular Patterns in Perioperative Anesthesia Care: A Clinical Perspective. [PDF]

Anesth Res
Maisat W, Yuki K.
europepmc   +1 more source

Compilation analysis of histones and histone genes

Nucleic Acids Research, 1986
openaire   +3 more sources

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Peptidylarginine Deiminases: An Overview of Recent Advances in Citrullination Research. [PDF]

Int J Mol Sci
Kijak-Boćkowska M, Czerwińska J, Owczarczyk-Saczonek A.   +2 more
europepmc   +1 more source

Effects of antineoplastic phospholipids on parameters of cell differentiation in U937 cells [PDF]

, 1990
Berkovic, D., Doenecke, D., Eibl, H., Hochhuth, C., Unger, C.   +4 more
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