Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation. [PDF]
PLoS ONE, 2016 The high circulating levels of histones found in various thrombotic diseases may compromise the anticoagulant barrier of endothelial cells. We determined how histones affect endothelial procoagulant tissue factor (TF) and anticoagulant thrombomodulin (TM)
Ji Eun Kim +3 more
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Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM
Frontiers in Molecular Biosciences, 2022 Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin +3 more
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MCM2 promotes symmetric inheritance of modified histones during DNA replication
Science, 2018 How cells ensure symmetric inheritance Parental histones with modifications are recycled to newly replicated DNA strands during genome replication, but do the two sister chromatids inherit modified histones equally? Yu et al. and Petryk et al.
N. Petryk +6 more
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Extracellular histones are major mediators of death in sepsis
Nature Network Boston, 2009 Hyperinflammatory responses can lead to a variety of diseases, including sepsis. We now report that extracellular histones released in response to inflammatory challenge contribute to endothelial dysfunction, organ failure and death during sepsis.
Jun Xu +9 more
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The Histone Database: an integrated resource for histones and histone fold-containing proteins [PDF]
Database, 2011 Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and ...
Andreas D. Baxevanis +6 more
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Abstract P-20: Linker Histone H1: The Interplay between Chromatosome Stability, Oncomutations and Post-Translational Modifications [PDF]
International Journal of Biomedicine, 2019 Background: Variations in the sequence of linker histone (LH) H1 play an important role in the modulation of chromatin functioning. Meanwhile, an effect of LH variations on the chromatin structure remains unclear.
Mikhail V. Bass +2 more
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ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.
Proceedings of the National Academy of Sciences of the United States of America, 1964 17 Ohno, S., and B. M. Cattanach, Cytogenet., 1, 129 (1962). 18 Russell, L. B., Science, 140, 976 (1963). 19 Lyon, M. F., Genetic Res., 4, 93 (1963). *' Benirschke, K., R. J. Low, L. E. Brownhill, L. B. Caday, and J.
V. Allfrey, R. Faulkner, A. Mirsky
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A novel role for lipid droplets in the organismal antibacterial response
eLife, 2012 We previously discovered histones bound to cytosolic lipid droplets (LDs); here we show that this forms a cellular antibacterial defense system. Sequestered on droplets under normal conditions, in the presence of bacterial lipopolysaccharide (LPS) or ...
Preetha Anand +10 more
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Frontiers in Genetics, 2021 A DNA double-strand break (DSB) takes place in the context of chromatin, and there is increasing evidence for chromatin structure to play a functional role in DSB signaling and repair.
Jieqiong Lou +7 more
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Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones.
Journal of the American Chemical Society, 2019 Histone ubiquitination affects the structure and function of nucleosomes through tightly regulated dynamic reversible processes. The efficient preparation of ubiquitinated histones and their analogs is important for biochemical and biophysical studies on
Guochao Chu +16 more
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