Results 21 to 30 of about 245,589 (335)

The role of histones in the immune responses of aquatic invertebrates [PDF]

Invertebrate Survival Journal, 2013
Histones are primary components of eukaryotic chromatin and highly abundant in all animal cells. In addition to their important role in chromatin structure and transcriptional regulation, histones contribute to innate immune responses. In several aquatic
C Nikapitiya, T Dorrington, M Gómez-Chiarri   +2 more
doaj   +1 more source

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken [PDF]

, 2005
The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals.
Bonifer, C., Bruce, K., Crane-Robinson, C., Greaves, I., Lefevre, P., Mantouvalou, E., Myers, F.A., Thorne, A.W., Tremethick, D.J.   +8 more
core   +5 more sources

The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria

mBio, 2023
Histone proteins are found across diverse lineages of Archaea, many of which package DNA and form chromatin. However, previous research has led to the hypothesis that the histone-like proteins of high-salt-adapted archaea, or halophiles, function ...
Saaz Sakrikar, Rylee K. Hackley, Mar Martinez-Pastor, Cynthia L. Darnell, Angie Vreugdenhil, Amy K. Schmid   +5 more
doaj   +1 more source

Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage

Biomolecules, 2023
Extracellular histones, part of the protein group known as damage-associated molecular patterns (DAMPs), are released from damaged or dying cells and can instigate cellular toxicity.
Mario C. Rico, Oscar Perez-Leal, Mary F. Barbe, Mamta Amin, Dennis J. Colussi, Magda L. Florez, Victor Olusajo, Dennise S. Rios, Carlos A. Barrero   +8 more
doaj   +1 more source

Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]

, 2016
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano, Gatla, Himavanth, Vancura, Ales, Vancurova, Ivana   +3 more
core   +2 more sources

ATP-dependent chromatosome remodeling [PDF]

, 2008
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S., Langst G., Loyola A., Ner S.S., Shogren-Knaak M., Varga-Weisz P.D., Wisniewski J.R.   +6 more
core   +1 more source

LPS-Challenged Macrophages Release Microvesicles Coated With Histones

Frontiers in Immunology, 2018
Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active ...
Rohini Ravindran Nair, Davide Mazza, Francesca Brambilla, Andrea Gorzanelli, Alessandra Agresti, Marco E. Bianchi   +5 more
doaj   +1 more source

Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus

Journal of Fungi, 2020
Antimicrobial peptides and proteins (AMPs) provide an important line of defence against invading microorganisms. However, the activity of AMPs against the human fungal pathogen Aspergillus fumigatus remains poorly understood.
Eloise Ballard, Raif Yucel, Willem J. G. Melchers, Alistair J. P. Brown, Paul E. Verweij, Adilia Warris   +5 more
doaj   +1 more source

Phasor Histone FLIM-FRET Microscopy Maps Nuclear-Wide Nanoscale Chromatin Architecture With Respect to Genetically Induced DNA Double-Strand Breaks

Frontiers in Genetics, 2021
A DNA double-strand break (DSB) takes place in the context of chromatin, and there is increasing evidence for chromatin structure to play a functional role in DSB signaling and repair.
Jieqiong Lou, Jieqiong Lou, Ashleigh Solano, Ashleigh Solano, Zhen Liang, Zhen Liang, Elizabeth Hinde, Elizabeth Hinde   +7 more
doaj   +1 more source

Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]

, 2008
Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core   +2 more sources