Results 21 to 30 of about 111,769 (244)

Histone chaperones regulate histone exchange during transcription [PDF]

The EMBO Journal, 2007
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway,
Hye-Jin, Kim, Ja-Hwan, Seol, Jeung-Whan, Han, Hong-Duk, Youn, Eun-Jung, Cho   +4 more
openaire   +2 more sources

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha, Binita Shrestha, Takashi Ito, Takashi Ito, Midori Kakuuchi, Takaaki Totoki, Tomoka Nagasato, Mika Yamamoto, Ikuro Maruyama   +8 more
doaj   +1 more source

The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria

mBio, 2023
Histone proteins are found across diverse lineages of Archaea, many of which package DNA and form chromatin. However, previous research has led to the hypothesis that the histone-like proteins of high-salt-adapted archaea, or halophiles, function ...
Saaz Sakrikar, Rylee K. Hackley, Mar Martinez-Pastor, Cynthia L. Darnell, Angie Vreugdenhil, Amy K. Schmid   +5 more
doaj   +1 more source

Elevated Plasma Histone H4 Levels Are an Important Risk Factor in the Development of Septic Cardiomyopathy

Balkan Medical Journal, 2020
Background:Myocardial impairment is a major complication and an important prognostic predictor of sepsis. Therefore, early and accurate diagnosis as well as timely management of septic cardiomyopathy is critical to achieve favorable outcomes.Aims:To ...
Nian-Fang Lu, Li Jiang, Bo Zhu, De-Gang Yang, Rui-Qiang Zheng, Jun Shao, Jing Yuan, Xiu-Ming Xi   +7 more
doaj   +1 more source

Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage

Biomolecules, 2023
Extracellular histones, part of the protein group known as damage-associated molecular patterns (DAMPs), are released from damaged or dying cells and can instigate cellular toxicity.
Mario C. Rico, Oscar Perez-Leal, Mary F. Barbe, Mamta Amin, Dennis J. Colussi, Magda L. Florez, Victor Olusajo, Dennise S. Rios, Carlos A. Barrero   +8 more
doaj   +1 more source

Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus

Journal of Fungi, 2020
Antimicrobial peptides and proteins (AMPs) provide an important line of defence against invading microorganisms. However, the activity of AMPs against the human fungal pathogen Aspergillus fumigatus remains poorly understood.
Eloise Ballard, Raif Yucel, Willem J. G. Melchers, Alistair J. P. Brown, Paul E. Verweij, Adilia Warris   +5 more
doaj   +1 more source

Phasor Histone FLIM-FRET Microscopy Maps Nuclear-Wide Nanoscale Chromatin Architecture With Respect to Genetically Induced DNA Double-Strand Breaks

Frontiers in Genetics, 2021
A DNA double-strand break (DSB) takes place in the context of chromatin, and there is increasing evidence for chromatin structure to play a functional role in DSB signaling and repair.
Jieqiong Lou, Jieqiong Lou, Ashleigh Solano, Ashleigh Solano, Zhen Liang, Zhen Liang, Elizabeth Hinde, Elizabeth Hinde   +7 more
doaj   +1 more source

Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis

Current Issues in Molecular Biology
Cellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta, Sauradeep Dutta, Payaningal R. Somanath, S. Priya Narayanan, Xiaoyun Wang, Duo Zhang   +5 more
doaj   +1 more source

Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM

Frontiers in Molecular Biosciences, 2022
Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin, Gang Feng, Chun Huang, Weijuan Cai   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source