Results 21 to 30 of about 61,334 (223)
Stochastic nucleosome disassembly mediated by remodelers and histone fragmentation [PDF]
arXiv, 2023 We construct and analyze monomeric and multimeric models of the stochastic disassembly of a single nucleosome. Our monomeric model predicts the time needed for a number of histone-DNA contacts to spontaneously break, leading to dissociation of a non-fragmented histone from DNA.
arxiv
mBio, 2023 Histone proteins are found across diverse lineages of Archaea, many of which package DNA and form chromatin. However, previous research has led to the hypothesis that the histone-like proteins of high-salt-adapted archaea, or halophiles, function ...
Saaz Sakrikar +5 more
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Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
Cells, 2022 NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil “explosion” and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins.
Rebeca Osca-Verdegal +8 more
doaj +1 more source
Frontiers in Plant Science, 2020 Chromatin regulation ensures stable repression of stress-inducible genes under non-stress conditions and transcriptional activation and memory of stress-related genes after stress exposure.
Kora Vyse +6 more
doaj +1 more source
Diseases, 2021 Lysine methylation is among the key posttranslational modifications to histones that contribute to epigenetic regulation. SMYD3 is a lysine methyltransferase that is essential for the proliferation of a range of tumorigenic cells. The findings that SMYD3
Dillon K. Jarrell +4 more
doaj +1 more source
Journal of Emergencies, Trauma and Shock, 2013 Background: Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to
Pär I Johansson +4 more
doaj +1 more source
H2A-H2B Histone Dimer Plasticity and Its Functional Implications
Cells, 2022 The protein core of the nucleosome is composed of an H3-H4 histone tetramer and two H2A-H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers lock the flanking DNA segments. Being positioned at the sides of the nucleosome,
Anastasiia S. Kniazeva +2 more
doaj +1 more source
A Proposal on Quantum Histone Modification in Gene Expression [PDF]
, 2012 A quantum mechanical model on histone modification is proposed. Along with the methyl / acetate or other groups bound to the modified residues the torsion angles of the nearby histone chain are supposed to participate in the quantum transition cooperatively.
arxiv +1 more source
Current Approaches to Epigenetic Therapy
Epigenomes, 2023 Epigenetic therapy is a promising tool for the treatment of a wide range of diseases. Several fundamental epigenetic approaches have been proposed. Firstly, the use of small molecules as epigenetic effectors, as the most developed pharmacological method,
Ekaterina D. Griazeva +10 more
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Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage
Biomolecules, 2023 Extracellular histones, part of the protein group known as damage-associated molecular patterns (DAMPs), are released from damaged or dying cells and can instigate cellular toxicity.
Mario C. Rico +8 more
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