Results 31 to 40 of about 317,398 (334)
Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation
Cell Death and Disease, 2016 In inflammation, extensive cell death may occur, which results in the release of chromatin components into the extracellular environment. Individually, the purified chromatin components double stranded (ds)DNA and histones have been demonstrated, both in
G. Marsman, S. Zeerleder, B. Luken
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Antigenicity of Histones [PDF]
Biochemical Journal, 1966 P Rümke, Mels Sluyser
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Serine is a new target residue for endogenous ADP-ribosylation on histones
Nature Chemical Biology, 2016 ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins.
Orsolya Leidecker +9 more
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Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
Frontiers in Immunology, 2019 Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha +8 more
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PLoS ONE, 2012 Neutrophils play an important role in innate immunity by defending the host organism against invading microorganisms. Antimicrobial activity of neutrophils is mediated by release of antimicrobial peptides, phagocytosis as well as formation of neutrophil ...
M. Saffarzadeh +7 more
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Frontiers in Neuroscience, 2022 The contribution of histone mark redistribution to the age-induced decline of endogenous neuroprotection remains unclear. In this study, we used an intracerebral hemorrhage (ICH)-induced acute brain injury rat model to study the transcriptional and ...
Qin Zhang +14 more
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Histones and histone modifications in protozoan parasites
Cellular Microbiology, 2006 Protozoan parasites are early branching eukaryotes causing significant morbidity and mortality in humans and livestock. Single-celled parasites have evolved complex life cycles, which may involve multiple host organisms, and strategies to evade host immune responses.
Sergio O. Angel +2 more
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The histone database: A comprehensive resource for histones and histone fold‐containing proteins [PDF]
Proteins: Structure, Function, and Bioinformatics, 2005 AbstractTheThe Histone Database is a curated and searchable collection of full‐length sequences and structures of histones and nonhistone proteins containing histone‐like folds, compiled from major public databases. Several new histone fold‐containing proteins have been identified, including the huntingtin‐interacting protein HYPM.
Andreas D. Baxevanis +3 more
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Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders
Journal of Cellular and Molecular Medicine, 2018 Histones are positively charged nuclear proteins that facilitate packaging of DNA into nucleosomes common to all eukaryotic cells. Upon cell injury or cell signalling processes, histones are released passively through cell necrosis or actively from ...
P. Szatmary +4 more
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mBio, 2023 Histone proteins are found across diverse lineages of Archaea, many of which package DNA and form chromatin. However, previous research has led to the hypothesis that the histone-like proteins of high-salt-adapted archaea, or halophiles, function ...
Saaz Sakrikar +5 more
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