Results 61 to 70 of about 317,398 (334)

The Role of Chromatin in Adenoviral Vector Function

Viruses, 2013
Vectors based on adenovirus (Ad) are one of the most commonly utilized platforms for gene delivery to cells in molecular biology studies and in gene therapy applications.
Carmen M. Wong, Emily R. McFall, Joseph K. Burns, Robin J. Parks   +3 more
doaj   +1 more source

Modern concepts of the molecular pathogenesis of thyroid cancer

Успехи молекулярной онкологии, 2021
Thyroid cancer remains the most common malignancy of the endocrine system worldwide. The indicators of its morbidity and mortality rates have been increasing rapidly over the last decades.
A. A. Mikhailova, A. V. Shestakov, K. A. Chubakova, E. V. Kolokolova, V. Yu. Eliseev, M. Ya. Kostyaeva, E. G. Akperov, V. E. Pilipenko, T. V. Saprina, M. R. Mukhamedov, E. L. Choinzonov   +10 more
doaj   +1 more source

Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN.

Journal of the American Society of Nephrology, 2015
Severe GN involves local neutrophil extracellular trap (NET) formation. We hypothesized a local cytotoxic effect of NET-related histone release in necrotizing GN.
Santhosh V Kumar, O. Kulkarni, S. R. Mulay, M. Darisipudi, S. Romoli, D. Thomasová, C. R. Scherbaum, B. Hohenstein, C. Hugo, Susanna Müller, H. Liapis, H. Anders   +11 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells

Brazilian Journal of Medical and Biological Research, 2000
Chromatin proteins play a role in the organization and functions of DNA. Covalent modifications of nuclear proteins modulate their interactions with DNA sequences and are probably one of the multiple factors involved in the process of switch on/off ...
J.C.F. Moreira, F. Dal-Pizzol, A.B. Rocha, F. Klamt, N.C. Ribeiro, C.J.S. Ferreira, E.A. Bernard   +6 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The Influence of Arginine Methylation in Immunity and Inflammation

Journal of Inflammation Research, 2022
Nivine Srour,1,2,* Sarah Khan,1,2,* Stephane Richard1,2 1Segal Cancer Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, H3T 1E2, Canada; 2Gerald Bronfman Department of Oncology, and Departments of ...
Srour N, Khan S, Richard S
doaj  

Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins

Microorganisms, 2018
Dinoflagellates are important eukaryotic microorganisms that play critical roles as producers and grazers, and cause harmful algal blooms. The unusual nuclei of dinoflagellates “dinokaryon„ have led researchers to investigate their enigmatic ...
Sadaf Riaz, Zhenghong Sui, Zeeshan Niaz, Sohrab Khan, Yuan Liu, Haoxin Liu   +5 more
doaj   +1 more source

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4.

Blood, 2011
The release of histones from dying cells is associated with microvascular thrombosis and, because histones activate platelets, this could represent a possible pathogenic mechanism.
F. Semeraro, C. Ammollo, J. Morrissey, G. Dale, P. Friese, N. Esmon, C. Esmon   +6 more
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source