Results 61 to 70 of about 245,589 (335)

Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells

Brazilian Journal of Medical and Biological Research, 2000
Chromatin proteins play a role in the organization and functions of DNA. Covalent modifications of nuclear proteins modulate their interactions with DNA sequences and are probably one of the multiple factors involved in the process of switch on/off ...
J.C.F. Moreira, F. Dal-Pizzol, A.B. Rocha, F. Klamt, N.C. Ribeiro, C.J.S. Ferreira, E.A. Bernard   +6 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Journal of Emergencies, Trauma and Shock, 2013
Background: Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to
Pär I Johansson, Nis A Windeløv, Lars S Rasmussen, Anne Marie Sørensen, Sisse R Ostrowski   +4 more
doaj   +1 more source

The size of the nucleosome [PDF]

, 2011
The structural origin of the size of the 11 nm nucleosomal disc is addressed. On the nanometer length-scale the organization of DNA as chromatin in the chromosomes involves a coiling of DNA around the histone core of the nucleosome.
A. Travers, Jakob Bohr, Kasper Olsen, S. M. West   +3 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Transcriptional and Post-Transcriptional Regulation and Transcriptional Memory of Chromatin Regulators in Response to Low Temperature

Frontiers in Plant Science, 2020
Chromatin regulation ensures stable repression of stress-inducible genes under non-stress conditions and transcriptional activation and memory of stress-related genes after stress exposure.
Kora Vyse, Léa Faivre, Melissa Romich, Majken Pagter, Daniel Schubert, Dirk K. Hincha, Ellen Zuther   +6 more
doaj   +1 more source

Earthworm coelomocyte extracellular traps : structural and functional similarities with neutrophil NETs [PDF]

, 2018
ROD UJ /
Joanna Homa
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structure and function of archaeal histones. [PDF]

PLoS Genetics, 2018
The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes.
Bram Henneman, Clara van Emmerik, Hugo van Ingen, Remus T Dame   +3 more
doaj   +1 more source

Extracting histones for the specific purpose of label-free MS [PDF]

, 2016
Extracting histones from cells is the first step in studies that aim to characterize histones and their post-translational modifications (hPTMs) with MS.
De Clerck, Laura, Deforce, Dieter, Dhaenens, Maarten, Govaert, Elisabeth, Meert, Paulien, Scheerlinck, Ellen, Stella, Martina, Van Steendam, Katleen, Vossaert, Liesbeth, Willems, Sander   +9 more
core   +2 more sources