Results 31 to 40 of about 135,562 (267)

HISTORICAL BASED LEARNING: INOVASI MODEL PEMBELAJARAN BERBASIS ANDRAGOGI

Paedagoria, 2023
Abstrak: Tujuan penulisan artikel ini yakni untuk membuat inovasi model pembelajaran sejarah pada mata kuliah Sejarah Indonesia Masa Hindu dan Buddha sehingga tujuan pembelajaran dapat tercapai.
Ismaul Fitroh, Joni Apriyanto, Resmiyati Yunus, Tonny Iskandar Mondong   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Cultural Penetration: Post-Modern Threat to Historical Learning

Indonesian Journal of History Education, 2023
According to the view of post-modernism in the world of education, humans are no longer subjects and actors to take advantage of science and technology but fall trapped into objects and targets controlled by science and technology as a product of ...
Yoan Mareta, Lisa Rukmana, Destri Yaldi
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

TEACHING HISTORICAL EMPATHY TROUGH REFLECTIVE LEARNING

Paramita: Historical Studies Journal, 2019
History does not only teach about certain facts or events that occurred in the past but also teaches about empathy since it emphasizes every aspect of human life. Students could learn about historical empathy trough reflective learning.
Indah Wahyu Puji Utami
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Ninguém ensina História... mas todo mundo aprende um pouco com ela: uma reflexão sobre as funções da História no Ensino Médio

História
RESUMO Neste artigo, apresento a ideia de que a História no Ensino Médio não é ensinável. Para sustentá-la, argumento que: 1) os acontecimentos históricos não são passíveis de ensinamento porque a res gestae é de natureza informativa e explicativa; 2 ...
Ricardo Marques de Mello
doaj   +1 more source

Perbedaan Tingkat Kesadaran Sejarah Siswa Menggunakan Sumber Belajar Situs Banten Lama Dengan Sumber Belajar LKS

Jurnal Paedagogy, 2022
This study aims to analyze the effects of using Banten Lama learning resources on increasing students' historical awareness and the differences in the historical understanding of students using Banten Lama learning resources and those using LKS learning ...
Ihya Alfi Azizi, Agus Rustamana, Arif Permana Putra   +2 more
doaj   +1 more source