Results 51 to 60 of about 945,741 (291)

The Past is a Foreign Country: But They Still Eat Ketchup There [PDF]

, 2011
Earlier this week, the folks over at the Gettysburg National Military Park Facebook page posted a link to their Gettysburg School Bus blog highlighting a post on integrating the Civil War into a language arts curriculum. I love the concept.
Rudy, John M.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Curriculum, historia atlántica y enseñanza de la historia: los desafíos de la BNCC Brasil (2015)

Clio y Asociados, 2019
The text explores the discussions about the curricular proposal of the 2015 BNCC that led to a break with the Eurocentric paradigm in the teaching of history content by proposing an Atlantic approach.
Edna Matos Antonio
doaj   +1 more source

Huebner\u27s Critical Encounter with the Philosophy of Heidegger in \u3cem\u3eBeing and Time\u3c/em\u3e: Learning, Understanding, and the Authentic Unfolding of History in the Curriculum [PDF]

, 2011
This paper responds to the following question: What are the issues concerned with potential educational reform that arise from Huebner\u27s critical encounter with Heidegger and the tradition in education and curriculum theory?
Magrini, James
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Independent Curriculum Reform on Aspects of Historical Thinking Skills in History Subjects in Senior High Schools

Scaffolding: Jurnal Pendidikan Islam dan Multikulturalisme
The aims of this research are (1) to plan history learning using the Merdeka curriculum for historical thinking skills, (2) to improve the Merdeka curriculum about aspects of history learning for historical thinking skills, and (3) to evaluate history ...
M. Ari Kuwoto, Leli Yulifar, Tarunasena Ma’mur   +2 more
doaj   +1 more source

Report on a Boston University Conference December 7-8, 2012 on 'How Can the History and Philosophy of Science Contribute to Contemporary U.S. Science Teaching?' [PDF]

, 2014
This is an editorial report on the outcomes of an international conference sponsored by a grant from the National Science Foundation (NSF) (REESE-1205273) to the School of Education at Boston University and the Center for Philosophy and History of ...
Benétreau-Dupin, Yann, Garik, Peter
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Curriculum implementation exploratory studies: Final report [PDF]

, 2009
Throughout the history of schooling in New Zealand the national curriculum has been revised at fairly regular intervals. Consequently, schools are periodically faced with having to accommodate to new curriculum.
Bolstad, Rachel, Boyd, Sally, Bull, Ally, Cooper, Beverley, Cowie, Bronwen, Ferrier-Kerr, Jenny L., Hipkins, Rosemary, Hume, Anne Christine, Keown, Paul Ashley, McGee, Clive, McKim, Anne M., Moreland, Judy, Morrison, Michele, Spiller, Lorraine, Taylor, Merilyn, Yates, Russell   +15 more
core   +1 more source