Results 61 to 70 of about 2,017,079 (263)

Nursing Home Implementation of Health Information Technology: Review of the Literature Finds Inadequate Investment in Preparation, Infrastructure, and Training. [PDF]

, 2018
Health information technology (HIT) is increasingly adopted by nursing homes to improve safety, quality of care, and staff productivity. We examined processes of HIT implementation in nursing homes, impact on the nursing home workforce, and related ...
Ko, Michelle, Spetz, Joanne, Wagner, Laura   +2 more
core   +2 more sources

Hitting HIV’s Harpoon [PDF]

Immunity, 2018
The HIV-1 fusion peptide is a target for broadly neutralizing antibodies. In a recent issue of Nature Medicine, Xu et al. (2018) provide proof-of-concept that vaccination with fusion peptide followed by vaccination with an envelope glycoprotein trimer can induce antibodies in animal models that neutralize diverse HIV-1 viruses.
van Gils, Marit J., Sanders, Rogier W.
openaire   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Randomized SMILES strings improve the quality of molecular generative models

Journal of Cheminformatics, 2019
Recurrent Neural Networks (RNNs) trained with a set of molecules represented as unique (canonical) SMILES strings, have shown the capacity to create large chemical spaces of valid and meaningful structures.
Josep Arús-Pous, Simon Viet Johansson, Oleksii Prykhodko, Esben Jannik Bjerrum, Christian Tyrchan, Jean-Louis Reymond, Hongming Chen, Ola Engkvist   +7 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Towards a Common Research Strategic Roadmap for the Transportation Sector in Europe and beyond [PDF]

Journal of Systemics, Cybernetics and Informatics, 2013
DETRA (Developing a European Transport Research Alliance) is a 7th Framework project, whose concept derived from the so-called Lyon Declaration and concerns the deepening of the European Research Area objectives in transport in order to address the Grand
Evangelos Bekiaris, Matina Loukea, Steve Phillips, Wolfgang Steinicke   +3 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening

SLAS Discovery
Fluorescent probe modulation assays are a widely used approach to monitor displacement or stabilisation of fluorescently labelled tool ligands by test compounds.
Alice Lanne, Catherine Bardelle, Gareth Davies, Antonia Turberville, Hannah Semple, Rachel Moore, Geoffrey A. Holdgate   +6 more
doaj   +1 more source

A novel method for the detection of R-peaks in ECG based on K-Nearest Neighbors and Particle Swarm Optimization

EURASIP Journal on Advances in Signal Processing, 2017
Cardiovascular diseases are associated with high morbidity and mortality. However, it is still a challenge to diagnose them accurately and efficiently. Electrocardiogram (ECG), a bioelectrical signal of the heart, provides crucial information about the ...
Runnan He, Kuanquan Wang, Qince Li, Yongfeng Yuan, Na Zhao, Yang Liu, Henggui Zhang   +6 more
doaj   +1 more source

Spielberg\u27s Dead Wrong about the Dead; or, The Places in the Movie Where I Cried [PDF]

, 2012
I stood in front of the rostrum in the National Cemetery with my parents. They hadn\u27t seen the movie yet. My best-friend was next to them. He hadn\u27t seen it yet.
Rudy, John M.
core   +1 more source