Results 1 to 10 of about 707,804 (298)
mBio, 2021 Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez +6 more
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HIV-1: To Splice or Not to Splice, That Is the Question
Viruses, 2021 The transcription of the HIV-1 provirus results in only one type of transcript—full length genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the genomic RNA must completely splice.
Ann Emery, Ronald Swanstrom
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BMJ Open, 2023 Objectives To describe the implementation of screening for cryptococcal antigenaemia by point-of-care (POC) serum cryptococcal antigen (CrAg) lateral flow assay, measure the prevalence and factors associated with serum cryptococcal antigenaemia in the ...
Amit Harshana +15 more
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HIV-1 Prevention for HIV-1 Serodiscordant Couples [PDF]
Current HIV/AIDS Reports, 2012 A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling ...
Curran, K +5 more
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HIV-1 transmission and acute HIV-1 infection [PDF]
British Medical Bulletin, 2001 An understanding of the central events in the transmission of HIV-1 infection is critical to the development of effective strategies to prevent infection. Although the main routes of transmission have been known for some time, surprisingly little is known about the factors that influence the likelihood of transmitting or acquiring HIV-1 infection. Once
Hansasuta, P, Rowland-Jones, S
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New England Journal of Medicine, 2011 In 2009, the United Nations estimated that 33.2 million people worldwide were living with human immunodeficiency virus type 1 (HIV-1) infection and that 2.6 million people had been newly infected.1 The need for effective HIV-1 prevention has never been greater.
Cohen, MS +3 more
openaire +3 more sources
HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission [PDF]
Journal of Virology, 2014 ABSTRACT The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N -glycans. HIV-1 Env N -glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure,
Ruizhong, Shen +4 more
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Chinese Medical Journal, 2023 . Background:. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), an inhibitory receptor expressed on T cells, plays a dysfunctional role in antiviral infection and antitumor activity.
Junyan Jin +15 more
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Targeting the HIV reservoir: chimeric antigen receptor therapy for HIV cure
Chinese Medical Journal, 2023 . Although antiretroviral therapy (ART) can reduce the viral load in the plasma to undetectable levels in human immunodeficiency virus (HIV)-infected individuals, ART alone cannot completely eliminate HIV due to its integration into the host cell genome ...
Shuang Li +6 more
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Retrovirology, 2018 Background The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency.
Shringar Rao +4 more
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