Results 101 to 110 of about 658,368 (320)

HIV-1 detection in the olfactory mucosa of HIV-1-infected participants

AIDS, 2019
HIV infection chronically affects the central nervous system (CNS). Olfactory mucosa is a unique site in the respiratory tract that is directly connected to the CNS; thus we wanted to evaluate olfactory mucosa as a surrogate of CNS sampling.We conducted a preliminary study examining HIV populations and susceptible cells in the olfactory mucosa ...
Bertero, Luca, Joseph, Sarah Beth, Trunfio, Mattia, Allice, Tiziano, Catera, Sebastiano, Imperiale, Daniele, Cassoni, Paola, Kincer, Laura Pesci, Pirriatore, Veronica, Ghisetti, Valeria, Amasio, Enrica, Zanusso, Gianluigi, Bonora, Stefano, Di Perri, Giovanni, Calcagno, Andrea   +14 more
openaire   +5 more sources

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

Advanced Science, EarlyView.
Network‐based risk stratification of people living with HIV (PWH) on prolonged therapy using multi‐omics data identifies 44% of the patients are at risk of immunometabolic complications. A senescence‐associated myeloid cell‐driven plasma microenvironment drives immunometabolic dysregulation in at‐risk PWH.
Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro de Magalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi   +32 more
wiley   +1 more source

Early Therapy in HIV-1-Infected Children: Effect on HIV-1 Dynamics and HIV-1-Specific Immune Response

Antiviral Therapy, 2008
Background Perinatal HIV-1 infection is acquired in the milieu of a developing immune system, leading to high levels of uncontrolled viral replication. Few data have been reported that address the viral dynamics and immunological response in infants who initiated aggressive antiretroviral therapy (ART) shortly after birth.
M. Zanchetta, A. Anselmi, D. Vendrame, O. Rampon, C. Giaquinto, A. Mazza, ACCAPEZZATO, DANIELE, BARNABA, Vincenzo, A. De Rossi   +8 more
openaire   +5 more sources

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors

Advanced Science, EarlyView.
A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan, Scott Lovell, Keith W Vance, Jody M Mason   +3 more
wiley   +1 more source

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids

Computational and Mathematical Biophysics, 2014
Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids.
Sadre-Marandi Farrah, Liu Jiangguo, Tavener Simon, Chen Chaoping   +3 more
doaj   +1 more source

Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides

Advanced Science, EarlyView.
The authors introduce a high‐throughput synthesis using amide‐sulfoxonium ylides as new nucleophilic reagents, enabling a catalyst‐ and base‐free hydrocarbonation of terminal alkynes under mild conditions, resulting in various E‐alkene substituted (hetero)amide‐sulfoxonium ylides with excellent regio‐ and stereoselectivity. The late‐stage modifications
Haiting Wu, Yougen Xu, An Lin, Jingyuan Liu, Huanjun Chen, Shimin Xie, Lebin Su   +6 more
wiley   +1 more source

(Q)SAR Models of HIV-1 Protein Inhibition by Drug-Like Compounds

Molecules, 2019
Despite the achievements of antiretroviral therapy, discovery of new anti-HIV medicines remains an essential task because the existing drugs do not provide a complete cure for the infected patients, exhibit severe adverse effects, and lead to the ...
Leonid A. Stolbov, Dmitry S. Druzhilovskiy, Dmitry A. Filimonov, Marc C. Nicklaus, Vladimir V. Poroikov   +4 more
doaj   +1 more source

In-vivo mutation rates and fitness landscape of HIV-1 [PDF]

arXiv, 2016
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we estimated mutation rates and fitness costs in HIV-1 from the temporal dynamics of genetic variation.
arxiv