Results 101 to 110 of about 25,225,361 (379)

ING116070: a study of the pharmacokinetics and antiviral activity of dolutegravir in cerebrospinal fluid in HIV-1-infected, antiretroviral therapy-naive subjects. [PDF]

, 2014
BackgroundDolutegravir (DTG), a once-daily, human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, was evaluated for distribution and antiviral activity in cerebrospinal fluid (CSF).MethodsING116070 is an ongoing, single-arm, open-label ...
Chen, Shuguang, extended ING116070 study team, Letendre, Scott L, Mills, Anthony M, Min, Sherene S, Piscitelli, Stephen C, Song, Ivy H, Tashima, Karen T, Thomas, Deborah A   +8 more
core   +3 more sources

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

A Neuronal and Neuroanatomical Correlate of HIV-1 Encephalopathy Relative to HIV-1 Encephalitis in HIV-1-infected Children [PDF]

Journal of Neuropathology and Experimental Neurology, 1997
Progressive central nervous system dysfunction analogous to the AIDS dementia complex (ADC) seen in adults (HIV-1-associated progressive encephalopathy or HIV-1 encephalopathy) commonly occurs in HIV-1-infected children. The cause appears to be directly or indirectly related to HIV-1, rather than to other opportunistic pathogens. The exact mechanism(s)
Leroy R. Sharer, Lee E. Eiden, Anna da Cunha, Anna da Cunha, Mark Mintz   +4 more
openaire   +3 more sources

A Twist in the Diagnosis: Chronic Arthropathy Without Inflammation

Arthritis Care &Research, EarlyView.
María Á. Puche‐Larrubia, Inmaculada C. Aranda‐Valera, Alejandro Escudero‐Contreras, Rosa Roldán‐Molina   +3 more
wiley   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection [PDF]

Open Biology, 2016
The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription.
Kristin Höhne, Ramona Businger, Anouk van Nuffel, Sebastian Bolduan, Herwig Koppensteiner, Ann Baeyens, Jolien Vermeire, Eva Malatinkova, Bruno Verhasselt, Michael Schindler   +9 more
doaj   +1 more source

Defective HIV-1 proviruses produce viral proteins

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance In HIV-infected patients on combination antiretroviral therapy (cART), greater than 95% of proviruses in the peripheral blood are “defective.” Historically, these defective proviruses have been thought to be dead-end products with no real ...
H. Imamichi, Mindy Smith, J. Adelsberger, Taisuke Izumi, F. Scrimieri, Brad T. Sherman, Catherine A. Rehm, T. Imamichi, A. Pau, M. Catálfamo, A. Fauci, H. Lane   +11 more
semanticscholar   +1 more source

Enhancement of HIV-1 proteinase activity by HIV-1 reverse transcriptase

Virology, 1995
HIV-1 reverse transcriptase (RT) was found to increase the activity of HIV-1 proteinase in vitro and in eukaryotic cells. The effect of RT on proteinase activity was dose-dependent and independent of pH or salt concentration. The cleavage of sequences corresponding to all the naturally occurring cleavage sites that could be tested in vitro was enhanced.
Laura Goobar-Larsson, G Utter, Bo Öberg, Bo Öberg, B. G. M. Luukkonen, B. Strandberg, Torsten Unge, Stefan Schwartz   +7 more
openaire   +3 more sources

Endocytic entry of HIV-1 [PDF]

Current Biology, 2000
Enveloped viruses enter target cells by membrane fusion or endocytosis. In the latter case, fusion of the viral envelope is induced by the acidic pH of the endocytic vesicle [1]. As with most other retroviruses, entry of the human immunodeficiency virus (HIV) is thought to be exclusively by pH-independent membrane fusion after interaction of its ...
B. Matija Peterlin, Oliver T. Fackler
openaire   +3 more sources

Cellular IP₆ Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP₆ Are Attenuated for Infection and Replication [PDF]

, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Böcking, Till, Faysal, K. M.Rifat, Fletcher, Adam J., Freed, Eric O., James, Leo C., Kleinpeter, Alex, Mallery, Donna L., Novikova, Mariia, Saiardi, Adolfo, Vaysburd, Marina, Wilson, Miranda S.C.   +10 more
core   +3 more sources