Results 11 to 20 of about 24,860,034 (345)
Retrovirology, 2013 Background The HIV virus hijacks cellular machineries to replicate. Post-translational modifications, like acetylation, phosphorylation or ubiquitination, are no exception. We are interested in studying the interplay between HIV and the SUMOylation pathway.
Beauclair, Guillaume +2 more
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Retrovirology, 2005 Abstract New York City health officials announced on February 11, 2005 that a patient rapidly developed full-blown AIDS shortly after being diagnosed with a rare, drug-resistant strain of HIV-1. The New York City Department of Health issued an alert to all hospitals and doctors and a press conference was held to announce the emergence of an ...
Berkhout, B. +2 more
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Cell, 2008 In 1981, the acquired immunodeficiency syndrome (AIDS) appeared insidiously and mystified doctors and scientists alike. No one could have predicted then that it would become, arguably, the worst plague in human history. Today, 33 million persons are living with infection by the human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS ...
Paul D. Bieniasz, David D. Ho
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HIV-1 transmission and acute HIV-1 infection [PDF]
British Medical Bulletin, 2001 An understanding of the central events in the transmission of HIV-1 infection is critical to the development of effective strategies to prevent infection. Although the main routes of transmission have been known for some time, surprisingly little is known about the factors that influence the likelihood of transmitting or acquiring HIV-1 infection. Once
Hansasuta, P, Rowland-Jones, S
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HIV-1 Prevention for HIV-1 Serodiscordant Couples [PDF]
Current HIV/AIDS Reports, 2012 A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling ...
Curran, K +5 more
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HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing [PDF]
Viruses, 2023 Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We propose a novel “block-lock-stop” approach, entailing long term durable silencing of viral expression ...
Danielle E. Lyons +22 more
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HIV-1 protease inhibitors and mechanisms of HIV-1's resistance. [PDF]
Glob Health MedCurrent anti-HIV drugs have significantly improved the prognosis of HIV infected patients so much so that it is now considered a chronic disease, and adherence to medications keeps non-detectable amounts of the virus in the body. However, HIV is still able to generate drug resistance substitutions.
Das D.
europepmc +3 more sources
Chinese Medical Journal, 2023 . Background:. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine can induce a potent cellular and humoral immune response to protect against SARS-CoV-2 infection.
Xiaodong Yang +14 more
doaj +1 more source
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway
Viruses, 2016 The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors
Valerie Le Sage +3 more
doaj +1 more source
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.
New England Journal of Medicine, 2009 BACKGROUND The development of a safe and effective vaccine against the human immunodeficiency virus type 1 (HIV-1) is critical to pandemic control. METHODS In a community-based, randomized, multicenter, double-blind, placebo-controlled efficacy trial ...
S. Rerks-Ngarm +23 more
semanticscholar +1 more source