Results 21 to 30 of about 25,225,361 (379)

HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing [PDF]

Viruses, 2023
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We propose a novel “block-lock-stop” approach, entailing long term durable silencing of viral expression ...
Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O’Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott   +22 more
openaire   +4 more sources

Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8+ T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine

Chinese Medical Journal, 2023
. Background:. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), an inhibitory receptor expressed on T cells, plays a dysfunctional role in antiviral infection and antitumor activity.
Junyan Jin, Xiuwen Wang, Yongzheng Li, Xiaodong Yang, Hu Wang, Xiaoxu Han, Jin Sun, Zhenglai Ma, Junyi Duan, Guanghui Zhang, Tao Huang, Tong Zhang, Hao Wu, Xin Zhang, Bin Su, Yanjie Yin   +15 more
doaj   +1 more source

Targeting the HIV reservoir: chimeric antigen receptor therapy for HIV cure

Chinese Medical Journal, 2023
. Although antiretroviral therapy (ART) can reduce the viral load in the plasma to undetectable levels in human immunodeficiency virus (HIV)-infected individuals, ART alone cannot completely eliminate HIV due to its integration into the host cell genome ...
Shuang Li, Hu Wang, Na Guo, Bin Su, Olivier Lambotte, Tong Zhang, Yanjie Yin   +6 more
doaj   +1 more source

The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level

Retrovirology, 2018
Background The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency.
Shringar Rao, Raquel Amorim, Meijuan Niu, Abdelkrim Temzi, Andrew J. Mouland   +4 more
doaj   +1 more source

MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients [PDF]

, 2015
BACKGROUND: Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine.
ANTONELLI, Guido, Cacciotti G, D'ETTORRE, Gabriella, FALASCA, FRANCESCA, MEZZAROMA, Ivano, MONTELEONE, Katia, SCAGNOLARI, CAROLINA, SELVAGGI, CARLA, TURRIZIANI, Ombretta, VULLO, Vincenzo   +9 more
core   +2 more sources

HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking

Frontiers in Cell and Developmental Biology, 2021
The human immunodeficiency virus (HIV-1) modifies the host cell environment to ensure efficient and sustained viral replication. Key to these processes is the capacity of the virus to hijack ATPases, GTPases and the associated proteins that control ...
Lucas A. Tavares, Yunan C. Januário, Luis L. P. daSilva   +2 more
doaj   +1 more source

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120 [PDF]

, 2001
BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations
A Boyum, A Robert Neurath, A Trkola, A Trkola, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, CD Rizzuto, CK Lapham, CM Javan, DR Burton, DR Littman, EA Berger, F Cocchi, G Alkhatib, H Choe, H Deng, J Bilello, JA Este, JC Lee, K Javaherian, KH Manson, L Wu, L Xiao, M Baba, M Baba, M Moulard, M Thali, MA Skinner, MC Peitsch, Nathan Strick, P Greenhead, PD Kwong, RA Anderson, RA Maguire, RF Speck, RJ Shattock, S Harada, S Laal, S Matsushita, S Rusconi, S Shaunak, T Dragic, T Gyotoku, T Kawamura, T Muster, TN Hart, WR Melander, Y Feng, YI Rumyantseva, Yun-Yao Li   +55 more
core   +3 more sources

HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex

mBio, 2016
Stress granules (SGs) are dynamic accumulations of stalled preinitiation complexes and translational machinery that assemble under stressful conditions.
Alessandro Cinti, Valerie Le Sage, Marwan Ghanem, Andrew J. Mouland   +3 more
doaj   +1 more source

Dificuldade sexual vivenciada por mulheres em crise de HIV-1 La dificultad sexual vivida por mujeres en crisis de HIV-1 Sexual problems experienced by women in an HIV-1 crisis

Revista Latino-Americana de Enfermagem, 2000
Esta pesquisa de caráter descritivo insere-se nos pressupostos dos métodos qualitativos de investigação, sendo fundamentada pela Teoria da Crise preconizada por CAPLAN (1966).
Mara Rúbia Ignácio de Freitas, Elucir Gir, Antonia Regina Furegatto Rodrigues   +2 more
doaj   +1 more source

Everything counts - a method to determine viral suppression among people living with HIV using longitudinal data for the HIV care continuum - results of two large, German, multi-center real-life cohort studies over 20 years (1999–2018)

BMC Public Health, 2021
Background The aim of this study was to develop a standardized method to reconstruct persons’ individual viral load (VL) courses to determine viral suppression and duration of viremia for the HIV care continuum in Germany using longitudinal cohort data ...
Daniel Schmidt, Christian Kollan, Matthias Stoll, Osamah Hamouda, Viviane Bremer, Tobias Kurth, Barbara Bartmeyer, the HIV-1 Seroconverter cohort, the ClinSurv HIV cohort   +8 more
doaj   +1 more source