Results 21 to 30 of about 24,860,034 (345)
Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription [PDF]
Retrovirology, 2006 Abstract Background Transcription of HIV-1 genes is activated by HIV-1 Tat protein, which induces phosphorylation of RNA polymerase II (RNAPII) C-terminal domain (CTD) by CDK9/cyclin T1. Earlier we showed that CDK2/cyclin E phosphorylates HIV-1 Tat in vitro.
Zachary Klase +10 more
openaire +4 more sources
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases
Scientific Reports, 2017 HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking machineries for protein synthesis and ...
Alessandro Cinti +8 more
doaj +1 more source
Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We Know
Viruses, 2020 Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is interrupted, a rapid rebound of viremia is observed.
Antoine Dutilleul +2 more
doaj +1 more source
Mathematical Biosciences and Engineering, 2021 We present the Progression and Transmission of HIV (PATH 4.0), a simulation tool for analyses of cluster detection and intervention strategies.
Sonza Singh +5 more
doaj +1 more source
Medicine, 2016 To assess the safety and efficacy of rilpivirine in combination with emtricitabine and tenofovir (RPV/FTC/TDF) as a once-daily single-tablet regimen (STR) in HIV-1-infected children and adolescents we performed a multicenter case series study of HIV-1 ...
Lola Falcón-Neyra +14 more
semanticscholar +1 more source
Nature Reviews Microbiology, 2018 This study used a large cohort of HIV-1 transmission pairs to determine the contribution of viral genetics on the development of neutralizing antibodies.
openaire +3 more sources
The HIV-1 transmission bottleneck [PDF]
Retrovirology, 2017 It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations in the blood of the presumed donor than to more abundant lineages.
Samuel Mundia Kariuki +6 more
openaire +5 more sources
Hiding in plain sight – platelets, the silent carriers of HIV-1
Platelets, 2021 There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer +11 more
doaj +1 more source
HIV-1 assembly in macrophages [PDF]
Retrovirology, 2010 The molecular mechanisms involved in the assembly of newly synthesized Human Immunodeficiency Virus (HIV) particles are poorly understood. Most of the work on HIV-1 assembly has been performed in T cells in which viral particle budding and assembly take place at the plasma membrane. In contrast, few studies have been performed on macrophages, the other
Michael Schindler +7 more
openaire +4 more sources
Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain
Viruses, 2021 The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms.
Javier E. Cañada +15 more
doaj +1 more source