Results 21 to 30 of about 658,368 (320)

Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription [PDF]

Retrovirology, 2006
Abstract Background Transcription of HIV-1 genes is activated by HIV-1 Tat protein, which induces phosphorylation of RNA polymerase II (RNAPII) C-terminal domain (CTD) by CDK9/cyclin T1. Earlier we showed that CDK2/cyclin E phosphorylates HIV-1 Tat in vitro.
Zachary Klase, Sharroya Charles, Tatyana Ammosova, Fatah Kashanchi, Marina Jerebtsova, Reem Berro, Sergei Nekhai, Sergei Nekhai, Angela Jackson, William M. Southerland, Victor R. Gordeuk   +10 more
openaire   +4 more sources

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases

Scientific Reports, 2017
HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking machineries for protein synthesis and ...
Alessandro Cinti, Valerie Le Sage, Miroslav P. Milev, Fernando Valiente-Echeverría, Christina Crossie, Marie-Joelle Miron, Nelly Panté, Martin Olivier, Andrew J. Mouland   +8 more
doaj   +1 more source

Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We Know

Viruses, 2020
Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is interrupted, a rapid rebound of viremia is observed.
Antoine Dutilleul, Anthony Rodari, Carine Van Lint   +2 more
doaj   +1 more source

In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway [PDF]

Nature Communications 2016; 7: 13689, 2016
HIV-1 virions assemble as immature particles containing Gag polyproteins that are processed by the viral protease into individual components, resulting in the formation of mature infectious particles. There are two competing models for the process of forming the mature HIV-1 core: the disassembly and de novo reassembly model and the non-diffusional ...
arxiv   +1 more source

The HIV-1 transmission bottleneck [PDF]

Retrovirology, 2017
It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations in the blood of the presumed donor than to more abundant lineages.
Samuel Mundia Kariuki, Samuel Mundia Kariuki, Samuel Mundia Kariuki, Kevin K. Ariën, Kevin K. Ariën, Philippe Selhorst, Jeffrey R. Dorfman   +6 more
openaire   +5 more sources

Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain

Viruses, 2021
The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms.
Javier E. Cañada, Elena Delgado, Horacio Gil, Mónica Sánchez, Sonia Benito, Elena García-Bodas, Carmen Gómez-González, Andrés Canut-Blasco, Joseba Portu-Zapirain, Ester Sáez de Adana, Mireia De la Peña, Sofía Ibarra, Gustavo Cilla, José Antonio Iribarren, Ana Martínez-Sapiña, Michael M. Thomson   +15 more
doaj   +1 more source

In silico prediction of mutant HIV-1 proteases cleaving a target sequence [PDF]

PLOS ONE Volume:9 Issue: 5 Page: e95833 (2014), 2014
HIV-1 protease represents an appealing system for directed enzyme re-design, since it has various different endogenous targets, a relatively simple structure and it is well studied. Recently Chaudhury and Gray (Structure (2009) 17: 1636 -- 1648) published a computational algorithm to discern the specificity determining residues of HIV-1 protease.
arxiv   +1 more source

Hiding in plain sight – platelets, the silent carriers of HIV-1

Platelets, 2021
There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer, Tina M. Weatherby, Brooks I. Mitchell, Ivo N. SahBandar, Thomas A. Premeaux, D’Antoni Michelle L., Cristhian A. Gutierrez-Huerta, Tiffany M. Powell-Wiley, Timothy R. Brown, William A. Boisvert, Cecilia M. Shikuma, Lishomwa C. Ndhlovu   +11 more
doaj   +1 more source

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]

PLOS Computational Biology. 2015 Apr 2;11(4):e1004179, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spreading mechanism, which is also a characteristic of some important computer worm outbreaks, to HIV-1 ...
arxiv   +1 more source

HIV-1 assembly in macrophages [PDF]

Retrovirology, 2010
The molecular mechanisms involved in the assembly of newly synthesized Human Immunodeficiency Virus (HIV) particles are poorly understood. Most of the work on HIV-1 assembly has been performed in T cells in which viral particle budding and assembly take place at the plasma membrane. In contrast, few studies have been performed on macrophages, the other
Michael Schindler, Mabel Jouve, Mabel Jouve, Philippe Benaroch, Raphael Gaudin, Raphael Gaudin, Elisabeth Billard, Elisabeth Billard   +7 more
openaire   +5 more sources