Results 31 to 40 of about 658,368 (320)
Reliable reconstruction of HIV-1 whole genome haplotypes reveals clonal interference and genetic hitchhiking among immune escape variants [PDF]
Retrovirology, 2014, 11:56, 2013 Following transmission, HIV-1 evolves into a diverse population, and next generation sequencing enables us to detect variants occurring at low frequencies. Studying viral evolution at the level of whole genomes was hitherto not possible because next generation sequencing delivers relatively short reads.
arxiv +1 more source
Nature Reviews Microbiology, 2018 This study used a large cohort of HIV-1 transmission pairs to determine the contribution of viral genetics on the development of neutralizing antibodies.
openaire +3 more sources
HIV-1 Nef: at the crossroads [PDF]
Retrovirology, 2008 The development of anti-virals has blunted the AIDS epidemic in the Western world but globally the epidemic has not been curtailed. Standard vaccines have not worked, and attenuated vaccines are not being developed because of safety concerns. Interest in attenuated vaccines has centered on isolated cases of patients infected with HIV-1 containing a ...
John L. Foster, J. Victor Garcia
openaire +4 more sources
Retrovirology, 2019 Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression.
Shringar Rao +5 more
doaj +1 more source
A Physical Theory of the Competition that Allows HIV to Escape from the Immune System [PDF]
, 2006 Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The
arxiv +1 more source
Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody [PDF]
, 2020 Broadly neutralizing antibodies are promising candidates for treatment and prevention of HIV-1 infections. Such antibodies can temporarily suppress viral load in infected individuals; however, the virus often rebounds by escape mutants that have evolved resistance.
arxiv +1 more source
American Journal of Community Psychology, Volume 70, Issue 3-4, Page 340-351, December 2022., 2022 Abstract Homelessness poses risks to the health and safety of young adults; particularly among sexual and gender minority (SGM) young adults. The current study sought to better understand service use and perceived safety in community and service settings among SGM and cisgender heterosexual (cis‐hetero) young adults experiencing homelessness. Data come
Graham DiGuiseppi +4 more
wiley +1 more source
All opinions are not equal: Toward a consensual approach to the development of drug policy
Australian Journal of Social Issues, Volume 57, Issue 4, Page 812-828, December 2022., 2022 Abstract Drug policy has been subjected to much scrutiny from different stakeholder groups who present sometimes very different opinions on solutions to address a problem. Reconciling such differences, that are underpinned by both anecdotal and empirical evidence, is a priority yet to be fully achieved.
Gabriel T. W. Wong, Matthew Manning
wiley +1 more source
Australian Journal of Social Issues, Volume 57, Issue 4, Page 829-846, December 2022., 2022 Abstract Introduction The inclusion of people who use drugs in the design and evaluation of their health services remains a relatively new phenomenon. The aim of the research was to explore the experiences and perceptions of people accessing the Medical Supervised Injecting Centre (MSIC), and Clinic 180, Sydney Australia, and the factors facilitating ...
Greg Rickard, Bethne Hart
wiley +1 more source
Vaccines, 2020 Most infections occur at mucosal surfaces. Providing a barrier of protection at these surfaces may be a useful strategy to combat the earliest events in infection when there are relatively few pathogens to address.
William E. Matchett +4 more
doaj +1 more source