Results 41 to 50 of about 24,954,598 (334)

Genetic Adjuvants in Replicating Single-Cycle Adenovirus Vectors Amplify Systemic and Mucosal Immune Responses against HIV-1 Envelope

Vaccines, 2020
Most infections occur at mucosal surfaces. Providing a barrier of protection at these surfaces may be a useful strategy to combat the earliest events in infection when there are relatively few pathogens to address.
William E. Matchett, Goda Baddage Rakitha Malewana, Haley Mudrick, Michael J. Medlyn, Michael A. Barry   +4 more
doaj   +1 more source

Immune-correlates analysis of an HIV-1 vaccine efficacy trial.

New England Journal of Medicine, 2012
BACKGROUND In the RV144 trial, the estimated efficacy of a vaccine regimen against human immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed a case-control analysis to identify antibody and cellular immune correlates of infection risk ...
B. Haynes, P. Gilbert, M. McElrath, S. Zolla-Pazner, G. Tomaras, S. Alam, David T. Evans, D. Montefiori, C. Karnasuta, R. Sutthent, H. Liao, A. Devico, G. Lewis, C. Williams, A. Pinter, Y. Fong, H. Janes, Allan C. deCamp, Yunda Huang, M. Rao, E. Billings, N. Karasavvas, M. Robb, V. Ngauy, M. de Souza, R. Paris, G. Ferrari, R. Bailer, K. Soderberg, C. Andrews, P. Berman, N. Frahm, S. D. De Rosa, M. Alpert, N. Yates, Xiaoying Shen, R. Koup, P. Pitisuttithum, J. Kaewkungwal, S. Nitayaphan, S. Rerks-Ngarm, N. Michael, Jerome H. Kim   +42 more
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Molecular Identification of HIV-1 in the Presence of Hepatitis B Virus and Hepatitis C Virus Co-infections

Balkan Medical Journal, 2020
Background: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis
Müge Özgüler, Figen Sarıgül Yıldırım, Taner Yıldırmak, Alper Gündüz, Başak Dokuzoğuz, Mustafa Kemal Çelen, Dilara İnan, Yasemin Heper, Gülden Ersöz, İlkay Karaoğlan, Nurgül Ceran, Aydın Deveci, Servet Öztürk, Selda Sayın Kutlu, Hülya Özkan Özdemir, Ayhan Akbulut, Saadet Yazıcı, Alper Şener, Atahan Çağatay, Serhat Ünal   +19 more
doaj   +1 more source

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells

Emerging Microbes and Infections, 2022
HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang   +12 more
doaj   +1 more source

Cryptococcal antigen among HIV1-infected individuals in north-central Nigeria [PDF]

Current Medical Mycology, 2020
Background and Purpose: The potential for the invasion of the central nervous system by Cryptococcus species is underscored by the presence of this organism in the blood of immunocompromised individuals.
Chimezie Ezenabike, Oluwaseyi Ashaka, Adesuyi Omoare, Abayomi Fadeyi, Alakija Salami, Olajide Agbede   +5 more
doaj   +1 more source

Antiretroviral Therapy for the Prevention of HIV-1 Transmission.

New England Journal of Medicine, 2016
BACKGROUND An interim analysis of data from the HIV Prevention Trials Network (HPTN) 052 trial showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked infections caused by human immunodeficiency virus type 1 (HIV-1) in ...
M. Cohen, Y. Chen, M. McCauley, T. Gamble, M. Hosseinipour, N. Kumarasamy, J. Hakim, J. Kumwenda, B. Grinsztejn, J. Pilotto, S. Godbole, S. Chariyalertsak, B. Santos, K. Mayer, I. Hoffman, S. Eshleman, E. Piwowar-Manning, L. Cottle, X. Zhang, J. Makhema, L. Mills, R. Panchia, Sharlaa Faesen, J. Eron, J. Gallant, D. Havlir, S. Swindells, V. Elharrar, David Burns, T. Taha, K. Nielsen‐Saines, D. Celentano, M. Essex, S. Hudelson, A. Redd, T. Fleming   +35 more
semanticscholar   +1 more source

Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections [PDF]

, 2004
During the past year, a group has argued that unsafe injections are a major if not the main mode of HIV-1 transmission\ud in sub-Saharan Africa. We review the main arguments used to question the epidemiological interpretations on the lead\ud role of ...
Abdala, Abdala, Allen, Anne Buvé, Anon, Auvert, Basia Zaba, Bird, Bongaarts, Brian G Williams, Brody, Bulterys, Cardo, Catherine Hankins, Chin, Clatts, Dicko, Dziekan, Ekpini, Fontanet, Gayle, Geoff P Garnett, George P Schmid, Gerbase, Gerberding, Gisselquist, Gisselquist, Gisselquist, Glynn, Gregson, Gregson, Gregson, Henderson, Hira, Hoelscher, Hutin, J Ties Boerma, James A Whitworth, Jesus Garcia Calleja, Kengeya-Kayondo, Kevin M De Cock, Killewo, MacPhail, Mann, Mbulaiteye, Merlin, Mertens, Mintz, Moses, Mulder, Mwalulo, Myers, N'Galy, Peter D Ghys, Peter Mugyenyi, Quigley, Quinn, Rich, Richard J Hayes, Robert Heimer, Rwandan HIV Seroprevalence Study Group, Saidi H Kapiga, Shisana, Smith, South African Ministry of Health, Uganda Bureau of Statistics (UBOS), Wadsworth, Wawer, Weiss, Weiss, WHO, Williams   +71 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Severe acute respiratory syndrome coronavirus 2-specific T-cell responses are induced in people living with human immunodeficiency virus after booster vaccination

Chinese Medical Journal
. Background:. T-cell-mediated immunity is crucial for the effective clearance of viral infection, but the T-cell-mediated immune responses that are induced by booster doses of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
Xiuwen Wang, Yongzheng Li, Junyan Jin, Xiaoran Chai, Zhenglai Ma, Junyi Duan, Guanghui Zhang, Tao Huang, Xin Zhang, Tong Zhang, Hao Wu, Yunlong Cao, Bin Su, Yanjie Yin   +13 more
doaj   +1 more source