Results 41 to 50 of about 658,368 (320)
Mathematical Analysis of the Probability of Spontaneous Mutations in HIV-1 Genome and Their Role in the Emergence of Resistance to Anti-Retroviral Therapy [PDF]
, 2017 $\textbf{Background:}$ High mutability of HIV is the driving force of antiretroviral drug resistance, which represents a medical care challenge. $\textbf{Method and Model Equation:}$ To detect the mutability of each gene in the HIV-1 genome; a mathematical analysis of HIV-1 genome is performed, depending on a linear relation wherein the probability ...
arxiv +1 more source
Quantifying the Sensitivity of HIV-1 Viral Entry to Receptor and Coreceptor Expression [PDF]
J. Phys. Chem. B, 2016, 120 (26), pp 6189-6199, 2018 Infection by many viruses begins with fusion of viral and cellular lipid membranes, followed by entry of viral contents into the target cell and ultimately, after many biochemical steps, integration of viral DNA into that of the host cell. The early steps of membrane fusion and viral capsid entry are mediated by adsorption to the cell surface, and ...
arxiv +1 more source
New England Journal of Medicine, 2011 In 2009, the United Nations estimated that 33.2 million people worldwide were living with human immunodeficiency virus type 1 (HIV-1) infection and that 2.6 million people had been newly infected.1 The need for effective HIV-1 prevention has never been greater.
Cohen, MS +3 more
openaire +4 more sources
Balkan Medical Journal, 2020 Background: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis
Müge Özgüler +19 more
doaj +1 more source
Emerging Microbes and Infections, 2022 HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen +12 more
doaj +1 more source
Cryptococcal antigen among HIV1-infected individuals in north-central Nigeria [PDF]
Current Medical Mycology, 2020 Background and Purpose: The potential for the invasion of the central nervous system by Cryptococcus species is underscored by the presence of this organism in the blood of immunocompromised individuals.
Chimezie Ezenabike +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective A substantial part of central nervous system (CNS) disorders remains unexplained, despite various new and minimally invasive diagnostic techniques. Within this rapidly developing diagnostic field, the precise role of brain biopsy is unknown.
Robin W. van Steenhoven +14 more
wiley +1 more source
Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies
Vaccines, 2020 The human antibody repertoire is generated by the recombination of different gene segments as well as by processes of somatic mutation. Together these mechanisms result in a tremendous diversity of antibodies that are able to combat various pathogens ...
Christoph Kreer +4 more
doaj +1 more source
Revisiting HIV-1 uncoating [PDF]
Retrovirology, 2010 HIV uncoating is defined as the loss of viral capsid that occurs within the cytoplasm of infected cells before entry of the viral genome into the nucleus. It is an obligatory step of HIV-1 early infection and accompanies the transition between reverse transcription complexes (RTCs), in which reverse transcription occurs, and pre-integration complexes ...
openaire +7 more sources
HIV-1: maternal prognosis [PDF]
Revista do Hospital das Clínicas, 2004 Profound modifications in the profile of patients are currently being observed within the epidemic context of AIDS, especially with respect to pauperization and feminization of the disease. The population most frequently affected is in the reproductive age, and among adults aged 18 to 24 years, the ratio is 1 man to 1 woman, a phenomenon occurring ...
El Beitune, Patrícia +3 more
openaire +5 more sources