Results 41 to 50 of about 25,225,361 (379)

HIV-1 assembly in macrophages [PDF]

Retrovirology, 2010
The molecular mechanisms involved in the assembly of newly synthesized Human Immunodeficiency Virus (HIV) particles are poorly understood. Most of the work on HIV-1 assembly has been performed in T cells in which viral particle budding and assembly take place at the plasma membrane. In contrast, few studies have been performed on macrophages, the other
Michael Schindler, Mabel Jouve, Mabel Jouve, Philippe Benaroch, Raphael Gaudin, Raphael Gaudin, Elisabeth Billard, Elisabeth Billard   +7 more
openaire   +4 more sources

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies

Nature reviews. Immunology, 2022
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its ...
B. Haynes, K. Wiehe, P. Borrow, K. Saunders, Bette Korber, K. Wagh, A. McMichael, G. Kelsoe, B. Hahn, F. Alt, G. Shaw   +10 more
semanticscholar   +1 more source

Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles [PDF]

, 2002
BACKGROUND: Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV ...
A Nicholls, A Robert Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AS Dimitrov, Asim K Debnath, CE Parker, CH Chen, CM Carr, CM Carr, DC Chan, DC Chan, DL LeDuc, DR Littman, E de Rosny, EG Cormier, EG Cormier, GB Melikyan, H Deng, I Munoz-Barroso, J Bentz, J Chen, JA McKeating, JJ Skehel, K Tan, KH Manson, M Farzan, M Lu, M Thali, MK Gorny, Nathan Strick, P Lusso, PD Kwong, PL Jones, QJ Sattentau, QJ Sattentau, QJ Sattentau, R Wyatt, R Wyatt, RA Furuta, RL Willey, RW Doms, S Gartner, S Jiang, S Jiang, SA Gallo, Shibo Jiang, SL Orloff, SP Layne, T Gyotoku, T Kawamura, T Korte, T Weber, T-C Chou, TN Hart, U Moebius, VA Johnson, W Weissenhorn, W Weissenhorn, X-Z Pan, Y Kliger, Yun-Yao Li   +67 more
core   +3 more sources

Hiding in plain sight – platelets, the silent carriers of HIV-1

Platelets, 2021
There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer, Tina M. Weatherby, Brooks I. Mitchell, Ivo N. SahBandar, Thomas A. Premeaux, D’Antoni Michelle L., Cristhian A. Gutierrez-Huerta, Tiffany M. Powell-Wiley, Timothy R. Brown, William A. Boisvert, Cecilia M. Shikuma, Lishomwa C. Ndhlovu   +11 more
doaj   +1 more source

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.

New England Journal of Medicine, 2021
BACKGROUND Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear. METHODS We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the ...
L. Corey, P. Gilbert, M. Juraska, D. Montefiori, L. Morris, S. Karuna, Srilatha Edupuganti, N. Mgodi, Allan C. deCamp, Erika Rudnicki, Yunda Huang, P. Gonzales, R. Cabello, C. Orrell, J. Lama, F. Laher, E. Lazarus, Jorge Sanchez, I. Frank, J. Hinojosa, M. Sobieszczyk, Kyle Marshall, P. Mukwekwerere, J. Makhema, L. Baden, J. Mullins, C. Williamson, J. Hural, M. McElrath, Carter Bentley, Simbarashe Takuva, Margarita M Gomez Lorenzo, D. Burns, Nicole Espy, A. Randhawa, Nidhi K. Kochar, E. Piwowar-Manning, D. Donnell, N. Sista, P. Andrew, J. Kublin, G. Gray, J. Ledgerwood, J. Mascola, M. Cohen   +44 more
semanticscholar   +1 more source

HIV-1’s fingerprint [PDF]

Nature Reviews Microbiology, 2018
This study used a large cohort of HIV-1 transmission pairs to determine the contribution of viral genetics on the development of neutralizing antibodies.
openaire   +3 more sources

Evolution of experimental design and research techniques in HIV-1 reservoir studies : a systematic review

, 2020
Although HIV-1 has evolved from a deadly to a chronic disease over the past 20 years, an HIV-1 cure is still lacking due to the presence of persisting cellular viral reservoirs which are spread throughout the body in different anatomical compartments ...
De Scheerder, Marie-Angélique, Depelseneer, Bram, Vandekerckhove, Linos, Wim, Trypsteen   +3 more
core   +1 more source

Immune compromise in HIV-1/HTLV-1 coinfection with paradoxical resolution of CD4 lymphocytosis during antiretroviral therapy: a case report [PDF]

, 2015
Human immunodeficiency virus type-1 (HIV-1) and human T lymphotropic virus type-1 (HTLV-1) infections have complex effects on adaptive immunity, with specific tropism for, but contrasting effects on, CD4 T lymphocytes: depletion with HIV-1, proliferation
Bangham, C, Basnayake, S, Cook, L, Kagdi, H, Pozniak, A, Rockwood, N, Taylor, GP   +6 more
core   +2 more sources

HIV-1 Nef: at the crossroads [PDF]

Retrovirology, 2008
The development of anti-virals has blunted the AIDS epidemic in the Western world but globally the epidemic has not been curtailed. Standard vaccines have not worked, and attenuated vaccines are not being developed because of safety concerns. Interest in attenuated vaccines has centered on isolated cases of patients infected with HIV-1 containing a ...
John L. Foster, J. Victor Garcia
openaire   +4 more sources