Results 71 to 80 of about 24,954,598 (334)

Defective proviruses rapidly accumulate during acute HIV-1 infection

Nature Network Boston, 2016
Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form that is not targeted by the immune system or by ART.
Katherine M. Bruner, Alexandra J Murray, Ross A. Pollack, M. Soliman, S. Laskey, A. Capoferri, J. Lai, M. Strain, S. Lada, R. Hoh, Y. Ho, D. Richman, S. Deeks, J. Siliciano, R. Siliciano   +14 more
semanticscholar   +1 more source

A Physical Theory of the Competition that Allows HIV to Escape from the Immune System

, 2006
Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies.
A. K. Abbas, Guanyu Wang, Michael W. Deem, P. W. Nelson   +3 more
core   +1 more source

Primary HIV-1 Infection Among Infants in sub-Saharan Africa: HPTN 024. [PDF]

, 2009
Our objectives were to assess clinical signs and diagnoses associated with primary HIV-1 infection among infants. We analyzed data from a clinical trial (HIV Prevention Trials Network Protocol 024) in sub-Saharan Africa.
Anthony Mwatha, Barbra Richardson, Bollinger, Boom, Chasela, Daar, Guay, Hecht, Horwood, Irving Hoffman, Jennifer S Read, Jones, Kahn, Karim Manji, Kinloch-de Loes, Lavreys, Lepage, Lynda Emel, Megan Valentine, Nozyce, Richardson, Robert L Goldenberg, Rouet, Schacker, Taha, Taha E Taha, Usha Sharma   +26 more
core   +2 more sources

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Development of a droplet digital polymerase chain reaction assay for the sensitive detection of total and integrated HIV-1 DNA

Chinese Medical Journal
. Background:. Total human immunodeficiency virus (HIV) DNA and integrated HIV DNA are widely used markers of HIV persistence. Droplet digital polymerase chain reaction (ddPCR) can be used for absolute quantification without needing a standard curve ...
Lin Yuan, Zhiying Liu, Xin Zhang, Feili Wei, Shan Guo, Na Guo, Lifeng Liu, Zhenglai Ma, Yunxia Ji, Rui Wang, Xiaofan Lu, Zhen Li, Wei Xia, Hao Wu, Tong Zhang, Bin Su, Yanjie Yin   +16 more
doaj   +1 more source

Evolution of the gut microbiome following acute HIV-1 infection

Microbiome, 2019
Background In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome.
Muntsa Rocafort, Marc Noguera-Julian, Javier Rivera, Lucía Pastor, Yolanda Guillén, Jost Langhorst, Mariona Parera, Inacio Mandomando, Jorge Carrillo, Víctor Urrea, Cristina Rodríguez, Maria Casadellà, Maria Luz Calle, Bonaventura Clotet, Julià Blanco, Denise Naniche, Roger Paredes   +16 more
doaj   +1 more source

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Nature, 2011
Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses.
Kasia Hrecka, Caili Hao, M. Gierszewska, Selene K Swanson, Małgorzata Kęsik-Brodacka, Smita Srivastava, L. Florens, M. Washburn, J. Skowroński   +8 more
semanticscholar   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Study protocol for assessment of the efficacy of calcium dobesilate versus placebo on SARS-CoV-2 viral load in outpatients with COVID-19 (CADOVID study): a randomised, placebo-controlled, double-blind, monocentric phase II trial

BMJ Open
Introduction SARS-CoV-2 mainly infects respiratory endothelial cells, which is facilitated through its spike protein binding to heparan sulphate. Calcium dobesilate (CaD) is a well-established, widely available vasoactive and angioprotective drug ...
Idris Guessous, Alexandra Calmy, Herve Spechbach, Julien Salamun, Tamara Da Silva, Pilar Ustero, Yvan Gosmain   +6 more
doaj   +1 more source

Leveraging Design of Experiments to Unravel the Amplification Mechanism of Single‐Molecule Wide‐Field Biosensors

Advanced Materials Interfaces, EarlyView.
Detecting single molecules on large interfaces is challenging due to minimal perturbations on the sensing surface. Some biological systems achieve this feat using amplification mechanisms, but their molecular foundations remain unclear. To investigate, a Design of Experiments (DoE) approach examines how pH and ionic strength in conditioning solutions ...
Michele Catacchio, Mariapia Caputo, Lucia Sarcina, Cinzia Di Franco, Matteo Piscitelli, Erika Castrignanò, Paolo Bollella, Gaetano Scamarcio, Eleonora Macchia, Luisa Torsi   +9 more
wiley   +1 more source