Results 71 to 80 of about 658,368 (320)
Optical Microfiber Biomedical Sensors: Classification, Applications, and Future Perspectives
Advanced Sensor Research, EarlyView.This review delves deeply into the various types of optical microfiber biosensors, grounded firmly in their fundamental principles, and underscores their indispensable roles in pushing forward biomedical advancements. It examines the latest advancements, challenges faced by these biosensors in practical applications, future directions, breakthroughs ...
Lili Liang +5 more
wiley +1 more source
BMJ OpenIntroduction SARS-CoV-2 mainly infects respiratory endothelial cells, which is facilitated through its spike protein binding to heparan sulphate. Calcium dobesilate (CaD) is a well-established, widely available vasoactive and angioprotective drug ...
Idris Guessous +6 more
doaj +1 more source
HIV-1 Reverse Transcription [PDF]
, 2014 Reverse transcription is an obligatory step in retrovirus replication in the course of which the retroviral RNA/DNA-dependent DNA polymerase (RT) copies the single-stranded positive sense RNA genome to synthesize the double-stranded viral DNA. At the same time the RT-associated RNaseH activity degrades the genomic RNA template, which has just been ...
Cimarelli, Andrea, Darlix, Jean-Luc
openaire +6 more sources
SnapShot: HIV-1 Proteins [PDF]
Cell, 2008 4 to 35 trimersTM Binds cell-surface receptors; mediates virus attachment and entry CD4 CD4 plus CCR5/CXCR4 mediate virion entry; major determinants of viral tropismChemokine receptors (CCR5 and CXCR4)C-type lectin receptors (DC-SIGN, Langerin) Virion capture; viral transmission from dendritic cells to T ...
Michael H. Malim, Chad M. Swanson
openaire +2 more sources
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Fluorine‐Directed Automated Mannoside Assembly
Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023 Motivated by the importance of fluorination in drug discovery, fluorine‐directed automated glycan assembly (AFGA) is disclosed. This strategy leverages the C(sp3)−F bond at C2 to enable α‐stereocontrolled glycosylation that eliminates the reliance on O‐based directing groups.
Charlotte S. Teschers, Ryan Gilmour
wiley +1 more source
Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery
Advanced Therapeutics, EarlyView.Here, glycol chitosan (GC)‐coated PLGA NPs are developed to enhance oral drug delivery by enabling dual‐pathway endocytosis via clathrin‐ and caveolae‐mediated mechanisms. Alginate layering coating on GC‐PLGA further improves oral insulin delivery, achieving sustained glucose reduction in diabetic mice.
Huiwen Pang +7 more
wiley +1 more source
Harnessing Avidity: Quantifying Entropic and Energetic Effects of Linker Length and Rigidity Required for Multivalent Binding of Antibodies to HIV-1 Spikes [PDF]
, 2018 Due to the low density of envelope (Env) spikes on the surface of HIV-1, neutralizing IgG antibodies rarely bind bivalently using both antigen-binding arms (Fabs) to crosslink between spikes (inter-spike crosslinking), instead resorting to weaker monovalent binding that is more sensitive to Env mutations.
arxiv +1 more source
A Neuronal and Neuroanatomical Correlate of HIV-1 Encephalopathy Relative to HIV-1 Encephalitis in HIV-1-infected Children [PDF]
Journal of Neuropathology and Experimental Neurology, 1997 Progressive central nervous system dysfunction analogous to the AIDS dementia complex (ADC) seen in adults (HIV-1-associated progressive encephalopathy or HIV-1 encephalopathy) commonly occurs in HIV-1-infected children. The cause appears to be directly or indirectly related to HIV-1, rather than to other opportunistic pathogens. The exact mechanism(s)
Leroy R. Sharer +4 more
openaire +3 more sources
Advanced Theory and Simulations, EarlyView.The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak +2 more
wiley +1 more source