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The mTOR Complex Controls HIV Latency [PDF]
Cell Host and Microbe, 2016 A population of CD4 T lymphocytes harboring latent HIV genomes can persist in patients on antiretroviral therapy, posing a barrier to HIV eradication.
Michael C Bassik +2 more
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Novel Triazolopyridine-Based BRD4 Inhibitors as Potent HIV-1 Latency Reversing Agents
ACS Medicinal Chemistry Letters, 2023Bromodomain-containing protein 4 (BRD4) inhibitors have been proven to be a promising option for anti-HIV-1 latency therapeutics. We herein describe the design, synthesis, and anti-HIV-1 latency bioevaluation of triazolopyridine derivatives as BRD4 inhibitors.
Yan-Kai Wang +13 more
openaire +2 more sources
2021
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb to secondary infections. There is currently no cure for HIV-1 infection, but Highly Active Anti-Retroviral Therapy (HAART) can ...
openaire +2 more sources
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb to secondary infections. There is currently no cure for HIV-1 infection, but Highly Active Anti-Retroviral Therapy (HAART) can ...
openaire +2 more sources
Antiretroviral drugs do not interfere with bryostatin-mediated HIV-1 latency reversal
Antiviral Research, 2015Although an effective combination of antiretroviral therapy (cART) controls HIV-1 viraemia in infected patients, viral latency established soon after infection hinders HIV-1 eradication. It has been shown that bryostatin-1 (BRY) inhibits HIV-infection in vitro and reactivates the latent virus through the protein kinase C-NF-κB pathway.
Marta, Martínez-Bonet +7 more
openaire +2 more sources
2022
Abstract A major barrier towards HIV-1 cure is the presence of a replication-competent latent reservoir that, upon treatment cessation, can spark viral rebound leading to disease progression. Pharmacological reactivation of the latent HIV-1 reservoir with Latency reversing agents (LRAs) is a first step toward ...
H.A.B. Prins +29 more
openaire +1 more source
Abstract A major barrier towards HIV-1 cure is the presence of a replication-competent latent reservoir that, upon treatment cessation, can spark viral rebound leading to disease progression. Pharmacological reactivation of the latent HIV-1 reservoir with Latency reversing agents (LRAs) is a first step toward ...
H.A.B. Prins +29 more
openaire +1 more source
MALAT1 is important for facilitating HIV-1 latency reversal in latently infected monocytes
GeneLong non-coding RNAs (lncRNAs) are long RNA transcripts with length >200 nucleotides that do not encode proteins. They play a crucial role in regulating HIV-1 infection, yet their involvement in myeloid cells remains underexplored. Myeloid cells are susceptible to HIV infection and contribute substantially to the latent HIV reservoir.
Ankita, Rai +9 more
openaire +2 more sources
Modeling latency reversal en HIV-1 infection
2016info:eu-repo/semantics ...
Ribeiro, Ruy M. +3 more
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Epigenetic silencing and blockade of latency reversal by an HIV-1 encoded antisense transcript
Abstract The mechanisms that regulate human immunodeficiency virus 1 (HIV-1) latency are not fully elucidated. We reported that an HIV-1 antisense transcript (AST) induces epigenetic modifications at the HIV-1 promoter causing a closed chromatin state that suppresses viral transcription.Rui, Li +8 more
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A novel HIV-1 latency reversing bromodomain inhibitor
2018Trabajo presentado en la VII Spanish Drug Discovery Network Meeting, celebrada en Barcelona, España, del 12 al 13 de noviembre de ...
Jordan, Albert, Abner, Erik
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