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Antiretroviral drugs do not interfere with bryostatin-mediated HIV-1 latency reversal
Antiviral Research, 2015Although an effective combination of antiretroviral therapy (cART) controls HIV-1 viraemia in infected patients, viral latency established soon after infection hinders HIV-1 eradication. It has been shown that bryostatin-1 (BRY) inhibits HIV-infection in vitro and reactivates the latent virus through the protein kinase C-NF-κB pathway.
Marta, Martínez-Bonet +7 more
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2021
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb to secondary infections. There is currently no cure for HIV-1 infection, but Highly Active Anti-Retroviral Therapy (HAART) can ...
openaire +2 more sources
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb to secondary infections. There is currently no cure for HIV-1 infection, but Highly Active Anti-Retroviral Therapy (HAART) can ...
openaire +2 more sources
2022
Abstract A major barrier towards HIV-1 cure is the presence of a replication-competent latent reservoir that, upon treatment cessation, can spark viral rebound leading to disease progression. Pharmacological reactivation of the latent HIV-1 reservoir with Latency reversing agents (LRAs) is a first step toward ...
H.A.B. Prins +29 more
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Abstract A major barrier towards HIV-1 cure is the presence of a replication-competent latent reservoir that, upon treatment cessation, can spark viral rebound leading to disease progression. Pharmacological reactivation of the latent HIV-1 reservoir with Latency reversing agents (LRAs) is a first step toward ...
H.A.B. Prins +29 more
openaire +1 more source
MALAT1 is important for facilitating HIV-1 latency reversal in latently infected monocytes
GeneLong non-coding RNAs (lncRNAs) are long RNA transcripts with length >200 nucleotides that do not encode proteins. They play a crucial role in regulating HIV-1 infection, yet their involvement in myeloid cells remains underexplored. Myeloid cells are susceptible to HIV infection and contribute substantially to the latent HIV reservoir.
Ankita, Rai +9 more
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Modeling latency reversal en HIV-1 infection
2016info:eu-repo/semantics ...
Ribeiro, Ruy M. +3 more
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Epigenetic silencing and blockade of latency reversal by an HIV-1 encoded antisense transcript
Abstract The mechanisms that regulate human immunodeficiency virus 1 (HIV-1) latency are not fully elucidated. We reported that an HIV-1 antisense transcript (AST) induces epigenetic modifications at the HIV-1 promoter causing a closed chromatin state that suppresses viral transcription.Rui, Li +8 more
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A novel HIV-1 latency reversing bromodomain inhibitor
2018Trabajo presentado en la VII Spanish Drug Discovery Network Meeting, celebrada en Barcelona, España, del 12 al 13 de noviembre de ...
Jordan, Albert, Abner, Erik
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Journal of Proteome Research
The latent reservoir of HIV-1 is a hidden fortress for escaping from the immune system and preventing antiretroviral therapy. The reversal of latent reservoirs is one of the key components of the HIV eradication strategy. Many natural diterpenoids exhibit a high activity of HIV latency reactivation. However, their functional targets are largely unknown.
Lianshuai Ding +5 more
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The latent reservoir of HIV-1 is a hidden fortress for escaping from the immune system and preventing antiretroviral therapy. The reversal of latent reservoirs is one of the key components of the HIV eradication strategy. Many natural diterpenoids exhibit a high activity of HIV latency reactivation. However, their functional targets are largely unknown.
Lianshuai Ding +5 more
openaire +2 more sources