Results 41 to 50 of about 4,485 (189)

Moving Toward a Functional Cure for HIV-1

Infectious Diseases & Immunity, 2021
. Despite the recent success of suppressing human immunodeficiency virus 1 (HIV-1) replication in the peripheral blood with antiretroviral therapy, elimination of the provirus from infected cells remains challenging because the virus can integrate into ...
Wen Kang, Yongtao Sun, Haijuan Wang
doaj   +1 more source

Investigating the ubiquitin-proteasome system for targeted reversal of HIV-1 latency [PDF]

, 2018
HIV is a worldwide epidemic, remaining the ever-present specter among all matters regarding blood or other bodily fluids, such as sexual intercourse, healthcare, blood transfusions, or even surgery, particularly in resource-poor areas. While antiretroviral drug therapy is highly successful in suppressing the virus and preventing transmission, it cannot
openaire   +2 more sources

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir [PDF]

, 2023
Source data from the article "Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir"
Basiel Cole (10532204), Marion Pardons (6407921), Linos Vanderkerckhove (15303023)   +2 more
core   +1 more source

Anti-HIV-1 ADCC Antibodies following Latency Reversal and Treatment Interruption [PDF]

Journal of Virology, 2017
ABSTRACT There is growing interest in utilizing antibody-dependent cellular cytotoxicity (ADCC) to eliminate infected cells following reactivation from HIV-1 latency. A potential barrier is that HIV-1-specific ADCC antibodies decline in patients on long-term antiretroviral therapy (ART) and may not be sufficient to eliminate ...
Lee, WS, Kristensen, AB, Rasmussen, TA, Tolstrup, M, Østergaard, L, Søgaard, OS, Wines, BD, Mark Hogarth, P, Reynaldi, A, Davenport, MP, Emery, S, Amin, J, Cooper, DA, Kan, VL, Fox, J, Gruell, H, Parsons, MS, Kent, SJ   +17 more
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Enhancer H3K27ac modulates T-cell stimulation and HIV-1 latency reversal. [PDF]

, 2020
(A) H3 modifications H3K27ac, H3K27me3 and H3K9me3 ChIP over the HIV-1 provirus. DNA and chromatin was isolated 48h after DMSO or PMA/i treatment of Bcl2-donor cells.
Birgitta Lindqvist (8378349), Sara Svensson Akusjärvi (5809793), J. Peter Svensson (8378355), Marios Dimitriou (8378352), Anders Sönnerborg (153581)   +4 more
core   +1 more source

Reversal of HIV-1 latency with anti-microRNA inhibitors [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Human immunodeficiency virus type 1 (HIV-1) latency is achieved when host cells contain integrated proviral DNA but do not produce viral particles. The virus remains in resting CD4 T-lymphocytes, evading host immune surveillance and antiviral drugs. When resting cells are activated, infectious viral particles are produced.
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The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

PLOS Pathogens, 2015
Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection. However, until now, approaches to reverse HIV-1 latency in humans have yielded mixed results.
Søgaard, OS, Graversen, ME, Leth, S, Olesen, R, Brinkmann, CR, Nissen, SK, Kjaer, AS, Schleimann, MH, Denton, PW, Hey-Cunningham, WJ, Koelsch, KK, Pantaleo, G, Krogsgaard, K, Sommerfelt, M, Fromentin, R, Chomont, N, Rasmussen, TA, Østergaard, L, Tolstrup, M   +18 more
openaire   +8 more sources

Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA [PDF]

Biology Open, 2020
Infection of HIV-1 remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as protein kinase C (PKC) agonists (e.g. ingenol A) or histone deacetylase (HDAC) inhibitors (e.g.
Jared P. Taylor, Lucas H. Armitage, Daniel L. Aldridge, Melanie N. Cash, Mark A. Wallet   +4 more
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T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin.

PLoS Pathogens, 2022
The reservoir of latently HIV-1 infected cells is heterogeneous. To achieve an HIV-1 cure, the reservoir of activatable proviruses must be eliminated while permanently silenced proviruses may be tolerated.
Birgitta Lindqvist, Bianca B Jütte, Luca Love, Wlaa Assi, Julie Roux, Anders Sönnerborg, Tugsan Tezil, Eric Verdin, J Peter Svensson   +8 more
doaj   +1 more source

A Comparison of Different Immune Activation Strategies to Reverse HIV-1 Latency

Open Forum Infectious Diseases, 2020
AbstractResting CD4+ T cells are the best characterized component of the latent reservoir. Activation of these CD4+ T cells is needed to optimize transcription and viral replication, and this strategy has been used to measure the inducible reservoir. There are several methods that can be used to activate CD4+ T cells, and in this study, we compared 3 ...
Garliss, Caroline C, Kwaa, Abena K, Blankson, Joel N   +2 more
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