Results 41 to 50 of about 3,675 (177)

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency.

PLoS Pathogens, 2023
Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh, Derek H Janssens, Patrick J Paddison, Edward P Browne, Steve Henikoff, Molly OhAinle, Michael Emerman   +6 more
doaj   +1 more source

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells

iScience
Summary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj   +1 more source

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.

PLoS Pathogens, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa   +13 more
doaj   +1 more source

Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment

Journal of Nanobiotechnology, 2019
Background The major obstacle impeding human immunodeficiency virus-1 (HIV-1) eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of long-lived latently infected resting CD4+ T cells. Due to the fact that no drug has
Ignacio Relaño-Rodríguez, Raquel Juárez-Sánchez, Carolina Pavicic, Eduardo Muñoz, Maria Ángeles Muñoz-Fernández   +4 more
doaj   +1 more source

Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1Research in context

EBioMedicine, 2019
Background: Despite the success of antiretroviral therapy (ART), latent HIV-1 continues to persist in a long-lived population of resting memory CD4+ T cells within those who are infected. Finding a safe and effective means to induce latency reversal (LR)
Jan Kristoff, Mariana L. Palma, Tatiana M. Garcia-Bates, Chengli Shen, Nicolas Sluis-Cremer, Phalguni Gupta, Charles R. Rinaldo, Robbie B. Mailliard   +7 more
doaj   +1 more source

Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2020
“Shock and kill” therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect of HIV or an arm of the immune system.
Eric S. Sorensen, Amanda B. Macedo, Rachel S. Resop, J. Natalie Howard, Racheal Nell, Indra Sarabia, Daniel Newman, Yanqin Ren, R. Brad Jones, Vicente Planelles, Adam M. Spivak, Alberto Bosque   +11 more
openaire   +2 more sources

HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency

Frontiers in Cellular and Infection Microbiology, 2022
HIV-1 infection remains non-curative due to the latent reservoir, primarily a small pool of resting memory CD4+ T cells bearing replication-competent provirus.
Raquel Crespo, Shringar Rao, Tokameh Mahmoudi, Tokameh Mahmoudi, Tokameh Mahmoudi   +4 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Ephedrine enhances HIV-1 reactivation from latency through elevating tumor necrosis factor receptor II (TNFRII) expression

Heliyon, 2019
HIV-1 persists during antiretroviral therapy (ART) due to long-lived and proliferating latently-infected host cells, with the outcome being an incomplete cure. The latently-infected cells, or reservoir cells, are transcriptionally absent and invisible to
Jutatip Panaampon, Eriko Kudo, Ryusho Kariya, Seiji Okada   +3 more
doaj   +1 more source

Epigenetic Regulation of HIV-1 Sense and Antisense Transcription in Response to Latency-Reversing Agents

Non-Coding RNA, 2023
Nucleosomes positioned on the HIV-1 5′ long terminal repeat (LTR) regulate sense transcription as well as the establishment and maintenance of latency. A negative-sense promoter (NSP) in the 3′ LTR expresses antisense transcripts with coding and non-coding activities. Previous studies identified cis-acting elements that modulate NSP activity.
Rui Li, Isabella Caico, Ziyan Xu, Mohammad Shameel Iqbal, Fabio Romerio   +4 more
openaire   +3 more sources