Results 41 to 50 of about 29,994,236 (203)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

DataSheet_1_Natural killer cells induce HIV-1 latency reversal after treatment with pan-caspase inhibitors.pdf

, 2022
The establishment of a latency reservoir is the major obstacle for a cure of HIV-1. The shock-and-kill strategy aims to reactivate HIV-1 replication in HIV -1 latently infected cells, exposing the HIV-1-infected cells to cytotoxic lymphocytes.
Robert van Domselaar (9436448), George Gourgi (14222852), Luca Love (12800641), Joana Furtado Milão (14222849), Lukas Derhaschnig (14222855), J. Peter Svensson (8378355), Anders Sönnerborg (153581)   +6 more
core   +1 more source

T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin.

PLoS Pathogens, 2022
The reservoir of latently HIV-1 infected cells is heterogeneous. To achieve an HIV-1 cure, the reservoir of activatable proviruses must be eliminated while permanently silenced proviruses may be tolerated.
Birgitta Lindqvist, Bianca B Jütte, Luca Love, Wlaa Assi, Julie Roux, Anders Sönnerborg, Tugsan Tezil, Eric Verdin, J Peter Svensson   +8 more
doaj   +1 more source

PKC inhibitors reveal PKC isoforms involved in HIV latency reversal and immunomodulation. [PDF]

J Virol
The reservoir of persistently latently infected cells is a major barrier to a cure for HIV infection. Protein kinase C (PKC) modulators can reverse HIV latency and could thus be useful “Kick” components in “Kick and Kill” approaches to a cure.
Zaikos TD, Pham V, Chou TC, Moran JA, Turner SR, Yu BH, Hourani R, Ranjan A, Zack JA, Wender PA, Marsden MD.   +10 more
europepmc   +2 more sources

Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA [PDF]

Biology Open, 2020
Infection of HIV-1 remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as protein kinase C (PKC) agonists (e.g. ingenol A) or histone deacetylase (HDAC) inhibitors (e.g.
Jared P. Taylor, Lucas H. Armitage, Daniel L. Aldridge, Melanie N. Cash, Mark A. Wallet   +4 more
openaire   +3 more sources

A Comparison of Different Immune Activation Strategies to Reverse HIV-1 Latency

Open Forum Infectious Diseases, 2020
AbstractResting CD4+ T cells are the best characterized component of the latent reservoir. Activation of these CD4+ T cells is needed to optimize transcription and viral replication, and this strategy has been used to measure the inducible reservoir. There are several methods that can be used to activate CD4+ T cells, and in this study, we compared 3 ...
Garliss, Caroline C, Kwaa, Abena K, Blankson, Joel N   +2 more
openaire   +2 more sources

Curaxin CBL0137 has the potential to reverse HIV‐1 latency

Journal of Medical Virology, 2019
AbstractA cure for human immunodeficiency virus type‐1 (HIV‐1) has been hampered by the limitation of current combination antiretroviral therapy (cART) to address the latent reservoirs in HIV‐1 patients. One strategy proposed to eradicate these reservoirs is the “shock and kill” approach, where latency‐reversing agents (LRAs) are used to reactivate and
Maxime J. Jean, Dawei Zhou, Guillaume Fiches, Weili Kong, Huachao Huang, Andrei Purmal, Katerina Gurova, Netty G. Santoso, Jian Zhu   +8 more
openaire   +3 more sources

Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression [PDF]

, 2010
Background: Previously, we showed that glioma pathogenesis related protein (GliPR) is induced in CEM T cells upon HIV-1 infection in vitro. To examine whether GliPR plays a role as HIV dependency factor (HDF), we tested the effect of GliPR suppression by
Scheuring Urban J, Oliver G Ottmann, Dietrich, Ursula, Capalbo Gianni, Scheuring, Urban J., Ursula Dietrich, Ottmann, Oliver G., Dietrich Ursula, Gianni Capalbo, Urban J Scheuring, Hoelzer, Dieter (Prof. Dr.), Müller-Kuller Thea, Hoelzer Dieter, Ottmann Oliver G, Dieter Hoelzer, Thea Müller-Kuller, Capalbo, Gianni, Müller-Kuller, Thea   +17 more
core   +1 more source

UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat

mBio, 2021
HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new ...
Taizhen Liang, Qiao Zhang, Ziyao Wu, Pei Chen, Yifan Huang, Shuwen Liu, Lin Li   +6 more
doaj   +1 more source

INVESTIGATING HIV-1 LATENCY REVERSAL UPON COGNATE ANTIGEN RECOGNITION IN CD4+ T CELLS FROM PEOPLE ON ANTIRETROVIRAL THERAPY [PDF]

, 2023
Despite the advancement in antiretroviral therapy (ART) which effectively prevents viral replication and transmission, there is no cure for Human Immunodeficiency Virus type 1 (HIV-1) infection.
Moskovljevic, Milica
core   +1 more source